AC   MF_04003;
DC   Protein; auto
TR   HAMAP; MF_04003; -; 1; level=0
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Names: PPV_L2
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ID   VL2
DE   RecName: Full=Minor capsid protein L2;
GN   Name=L2;
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CC   -!- FUNCTION: Minor protein of the capsid that localizes along the inner
CC       surface of the virion, within the central cavities beneath the L1
CC       pentamers. Plays a role in capsid stabilization through interaction
CC       with the major capsid protein L1. Once the virion enters the host cell,
CC       L2 escorts the genomic DNA into the nucleus by promoting escape from
CC       the endosomal compartments and traffic through the host Golgi network.
CC       Mechanistically, the C-terminus of L2 possesses a cell-penetrating
CC       peptide that protudes from the host endosome, interacts with host
CC       cytoplasmic retromer cargo and thereby mediates the capsid delivery to
CC       the host trans-Golgi network. Plays a role through its interaction with
CC       host dynein in the intracellular microtubule-dependent transport of
CC       viral capsid toward the nucleus. Mediates the viral genome import into
CC       the nucleus through binding to host importins. Once within the nucleus,
CC       L2 localizes viral genomes to host PML bodies in order to activate
CC       early gene expression for establishment of infection. Later on,
CC       promotes late gene expression by interacting with the viral E2 protein
CC       and by inhibiting its transcriptional activation functions. During
CC       virion assembly, encapsidates the genome by direct interaction with the
CC       viral DNA.
CC   -!- SUBUNIT: Interacts with major capsid protein L1. Interacts with E2;
CC       this interaction inhibits E2 transcriptional activity but not the DNA
CC       replication function E2. Interacts with host HSPA8; this interaction is
CC       required for L2 nuclear translocation. Interacts with host importins
CC       KPNB2 and KPNB3. Forms a complex with importin alpha2-beta1
CC       heterodimers via interaction with the importin alpha2 adapter.
CC       Interacts with host DYNLT1; this interaction is essential for virus
CC       intracellular transport during entry. Interacts (via C-terminus) with
CC       host retromer subunits VPS35 AND VPS29.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus.
CC   -!- PTM: Highly phosphorylated.
CC   -!- SIMILARITY: Belongs to the papillomaviridae L2 protein family.
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DR   Pfam; PF00513; Late_protein_L2; 1; trigger=no
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KW   Capsid protein
KW   Cytoplasmic inwards viral transport
case <FTTag:disulfid>
KW   Disulfide bond
end case
KW   DNA-binding
KW   Host nucleus
KW   Host-virus interaction
KW   Late protein
KW   Microtubular inwards viral transport
KW   Phosphoprotein
KW   Viral penetration into host nucleus
KW   Virion
KW   Virus entry into host cell
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GO   GO:0042025; C:host cell nucleus
GO   GO:0019028; C:viral capsid
GO   GO:0003677; F:DNA binding
GO   GO:0005198; F:structural molecule activity
GO   GO:0075521; P:microtubule-dependent intracellular transport of viral material towards nucleus
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FT   From: VL2_HPV16 (P03107)
FT   MOTIF           1..13
FT                   /note="Nuclear localization signal"
FT   MOTIF           454..462
FT                   /note="Nuclear localization signal"
FT   DISULFID        22..28
FT   Tag: disulfid; Condition: C-x*-C
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Size: 357-554;
Related: None;
Template: P03107;
Scope:
 Viruses; Papillomaviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.7 2019/11/20
//