AC   MF_04004;
DC   Protein; auto
TR   HAMAP; MF_04004; -; 1; level=0
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Names: PPV_E7
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ID   VE7
DE   RecName: Full=Protein E7;
GN   Name=E7;
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CC   -!- FUNCTION: Plays a role in viral genome replication by driving entry of
CC       quiescent cells into the cell cycle. Stimulation of progression from G1
CC       to S phase allows the virus to efficiently use the cellular DNA
CC       replicating machinery to achieve viral genome replication. E7 protein
CC       has both transforming and trans-activating activities. Induces the
CC       disassembly of the E2F1 transcription factor from RB1, with subsequent
CC       transcriptional activation of E2F1-regulated S-phase genes. Interferes
CC       with host histone deacetylation mediated by HDAC1 and HDAC2, leading to
CC       transcription activation. Plays also a role in the inhibition of both
CC       antiviral and antiproliferative functions of host interferon alpha.
CC       Interaction with host TMEM173/STING impairs the ability of
CC       TMEM173/STING to sense cytosolic DNA and promote the production of type
CC       I interferon (IFN-alpha and IFN-beta).
CC   -!- SUBUNIT: Homodimer. Homooligomer. Interacts with host RB1; this
CC       interaction induces dissociation of RB1-E2F1 complex thereby disrupting
CC       RB1 activity. Interacts with host EP300; this interaction represses
CC       EP300 transcriptional activity. Interacts with protein E2; this
CC       interaction inhibits E7 oncogenic activity. Interacts with host
CC       TMEM173/STING; this interaction impairs the ability of TMEM173/STING to
CC       sense cytosolic DNA and promote the production of type I interferon
CC       (IFN-alpha and IFN-beta).
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Host nucleus. Note=Predominantly
CC       found in the host nucleus.
CC   -!- DOMAIN: The E7 terminal domain is an intrinsically disordered domain,
CC       whose flexibility and conformational transitions confer target
CC       adaptability to the oncoprotein. It allows adaptation to a variety of
CC       protein targets and exposes the PEST degradation sequence that
CC       regulates its turnover in the cell.
CC   -!- PTM: Highly phosphorylated.
CC   -!- SIMILARITY: Belongs to the papillomaviridae E7 protein family.
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DR   Pfam; PF00527; E7; 1; trigger=no
DR   PIRSF; PIRSF003407; Papvi_E7; 1; trigger=no
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KW   Activator
KW   DNA-binding
KW   Early protein
KW   G1/S host cell cycle checkpoint dysregulation by virus
KW   Host cytoplasm
KW   Host nucleus
KW   Host-virus interaction
KW   Inhibition of host innate immune response by virus
KW   Inhibition of host interferon signaling pathway by virus
KW   Metal-binding
KW   Modulation of host cell cycle by virus
KW   Transcription
KW   Transcription regulation
KW   Viral immunoevasion
KW   Zinc
KW   Zinc-finger
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GO   GO:0003677; F:DNA binding
GO   GO:0046872; F:metal ion binding
GO   GO:0019904; F:protein domain specific binding
GO   GO:0003700; F:DNA-binding transcription factor activity
GO   GO:0039645; P:perturbation by virus of host G1/S transition checkpoint
GO   GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway
GO   GO:0006351; P:DNA-templated transcription
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FT   From: VE7_HPV16 (P03129)
FT   ZN_FING         58..94
FT   REGION          Nter..40
FT                   /note="E7 terminal domain"
FT   Condition: C-x*-C-x-x-C
FT   MOTIF           22..26
FT                   /note="LXCXE motif; interaction with host RB1 and
FT                   TMEM173/STING"
FT   Condition: L-x-C-x-E
FT   MOTIF           76..84
FT                   /note="Nuclear export signal"
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Size: 86-127;
Related: None;
Template: P03129;
Scope:
 Viruses; Papillomaviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.11 2023/07/28
//