AC   MF_04007;
DC   Protein; auto
TR   HAMAP; MF_04007; -; 1; level=0
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Names: HSV_DNBI
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ID   DNBI
DE   RecName: Full=Major DNA-binding protein;
GN   Name=DBP;
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CC   -!- FUNCTION: Plays several crucial roles in viral infection. Participates
CC       in the opening of the viral DNA origin to initiate replication by
CC       interacting with the origin-binding protein. May disrupt loops,
CC       hairpins and other secondary structures present on ssDNA to reduce and
CC       eliminate pausing of viral DNA polymerase at specific sites during
CC       elongation. Promotes viral DNA recombination by performing strand-
CC       transfer, characterized by the ability to transfer a DNA strand from a
CC       linear duplex to a complementary single-stranded DNA circle. Can also
CC       catalyze the renaturation of complementary single strands.
CC       Additionally, reorganizes the host cell nucleus, leading to the
CC       formation of prereplicative sites and replication compartments. This
CC       process is driven by the protein which can form double-helical
CC       filaments in the absence of DNA.
CC   -!- SUBUNIT: Homooligomers. Forms double-helical filaments necessary for
CC       the formation of replication compartments within the host nucleus.
CC       Interacts with the origin-binding protein. Interacts with the helicase
CC       primase complex; this interaction stimulates primer synthesis activity
CC       of the helicase-primase complex. Interacts with the DNA polymerase.
CC       Interacts with the alkaline exonuclease; this interaction increases its
CC       nuclease processivity.
CC   -!- SUBCELLULAR LOCATION: Host nucleus. Note=In the absence of DNA
CC       replication, found in the nuclear framework-associated structures
CC       (prereplicative sites). As viral DNA replication proceeds, it migrates
CC       to globular intranuclear structures (replication compartments).
CC   -!- SIMILARITY: Belongs to the herpesviridae major DNA-binding protein
CC       family.
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DR   Pfam; PF00747; Viral_DNA_bp; 1; trigger=no
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KW   DNA replication
KW   DNA-binding
KW   Host nucleus
case <FTTag:Zn>
KW   Metal-binding
KW   Zinc
KW   Zinc-finger
end case
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case <FTTag:Zn>
GO   GO:0046872; F:metal ion binding
end case
GO   GO:0042025; C:host cell nucleus
GO   GO:0003697; F:single-stranded DNA binding
GO   GO:0006260; P:DNA replication
GO   GO:0039686; P:bidirectional double-stranded viral DNA replication
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FT   From: DNBI_HHV11 (P04296)
FT   ZN_FING         499..512
FT   Tag: Zn; Condition: C-x-x-C-x-x-x-x-x-x-x-C-x-H
FT   MOTIF           843..844
FT                   /note="Required for filament formation"
FT   Condition: F-W
FT   MOTIF           1142..1144
FT                   /note="Required for filament formation"
FT   Condition: F-N-F
FT   REGION          1170..Cter
FT                   /note="Required for nuclear localization"
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Size: 1127-1209;
Related: None;
Template: P04296; P36384;
Scope:
 Viruses; Herpesviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.4 2019/11/20
//