AC   MF_04010;
DC   Protein; auto
TR   HAMAP; MF_04010; -; 1; level=0
XX
Names: HSV_HEPA
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ID   HEPA
DE   RecName: Full=DNA helicase/primase complex-associated protein;
DE            Short=HEPA;
DE   AltName: Full=Primase-associated factor;
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CC   -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC       the replication forks and generates single-stranded DNA for both
CC       leading and lagging strand synthesis. The primase synthesizes short RNA
CC       primers on the lagging strand that the polymerase presumably elongates
CC       using dNTPs. The primase-associated factor has no known catalytic
CC       activity in the complex and may serve to facilitate the formation of
CC       the replisome by directly interacting with the origin-binding protein
CC       and the polymerase.
CC   -!- SUBUNIT: Associates with the primase and the helicase to form the
CC       helicase-primase complex. Interacts with the origin-binding protein.
CC       Interacts with the polymerase catalytic subunit.
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the herpesviridae HEPA family.
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DR   Pfam; PF03324; Herpes_HEPA; 1; trigger=no
DR   Pfam; PF05774; Herpes_heli_pri; 1; trigger=no
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KW   DNA replication
KW   Host nucleus
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GO   GO:0042025; C:host cell nucleus
GO   GO:0039686; P:bidirectional double-stranded viral DNA replication
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FT   None
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Size: 610-873;
Related: None;
Template: P10192;
Scope:
 Viruses; Herpesviridae
Fusion:
 Nter: None
 Cter: None
Plasmid: None
Comments: None
XX
# Revision 1.3 2019/11/20
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