AC   MF_04011;
DC   Protein; auto
TR   HAMAP; MF_04011; -; 1; level=0
XX
Names: HSV_PRIM
XX
ID   PRIM
DE   RecName: Full=DNA primase;
DE            EC=2.7.7.-;
XX
CC   -!- FUNCTION: Essential component of the helicase/primase complex. Unwinds
CC       the DNA at the replication forks and generates single-stranded DNA for
CC       both leading and lagging strand synthesis. The primase initiates primer
CC       synthesis and thereby produces large amount of short RNA primers on the
CC       lagging strand that the polymerase elongates using dNTPs.
CC   -!- SUBUNIT: Associates with the helicase and the primase-associated factor
CC       to form the helicase-primase factor.
CC   -!- SUBCELLULAR LOCATION: Host nucleus. Note=Requires the presence of the
CC       primase associated factor to properly localize in the host cell
CC       nucleus.
CC   -!- SIMILARITY: Belongs to the herpesviridae DNA primase family.
XX
DR   Pfam; PF03121; Herpes_UL52; 1; trigger=no
XX
KW   DNA replication
KW   Host nucleus
KW   Metal-binding
KW   Transferase
KW   Zinc
KW   Zinc-finger
XX
GO   GO:0042025; C:host cell nucleus
GO   GO:0003896; F:DNA primase activity
GO   GO:0039686; P:bidirectional double-stranded viral DNA replication
XX
FT   From: PRIM_HHV11 (P10236)
FT   ZN_FING         988..1028
FT                   /note="CHC2-type"
FT   Condition: C-x(4)-H-x*-C-x(4)-C
FT   SITE            628
FT                   /note="Essential for primase activity"
FT   Condition: D
FT   SITE            630
FT                   /note="Essential for primase activity"
FT   Condition: D
XX
Size: 835-1293;
Related: None;
Template: P10236;
Scope:
 Viruses; Herpesviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.4 2019/11/20
//