AC   MF_04013;
DC   Protein; auto
TR   HAMAP; MF_04013; -; 1; level=0
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Names: HSV_TRM3
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ID   TRM3
DE   RecName: Full=Tripartite terminase subunit 3;
DE            EC=3.1.-.-;
DE   AltName: Full=Terminase large subunit;
GN   Name=TRM3;
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CC   -!- FUNCTION: Component of the molecular motor that translocates viral
CC       genomic DNA in empty capsid during DNA packaging. Forms a tripartite
CC       terminase complex together with TRM1 and TRM2 in the host cytoplasm.
CC       Once the complex reaches the host nucleus, it interacts with the capsid
CC       portal vertex. This portal forms a ring in which genomic DNA is
CC       translocated into the capsid. TRM3 carries an RNase H-like nuclease
CC       activity that plays an important role for the cleavage of concatemeric
CC       viral DNA into unit length genomes.
CC   -!- SUBUNIT: Interacts with the terminase subunits TRM1 and TRM2. Interacts
CC       with portal protein.
CC   -!- SUBCELLULAR LOCATION: Host nucleus. Note=Responsible for the nuclear
CC       localization of the two others subunits TRM1 and TRM2.
CC   -!- SIMILARITY: Belongs to the herpesviridae TRM3 protein family.
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DR   Pfam; PF02499; DNA_pack_C; 1; trigger=no
DR   Pfam; PF02500; DNA_pack_N; 1; trigger=no
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KW   DNA-binding
KW   Host nucleus
KW   Hydrolase
KW   Viral genome packaging
KW   Viral release from host cell
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GO   GO:0042025; C:host cell nucleus
GO   GO:0051276; P:chromosome organization
GO   GO:0019076; P:viral release from host cell
GO   GO:0004518; F:nuclease activity
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FT   From: TRM3_HHV11 (P04295)
case <OC:Alphaherpesvirinae>
FT   MOTIF           183..189
FT                   /note="Nuclear localization signal"
end case
FT   MOTIF           258..265
FT                   /note="Walker A motif"
FT   Condition: [VI]-P-R-R-H-G-K-T
FT   MOTIF           352..357
FT                   /note="Walker B motif"
FT   Condition: [LI]-L-[FYLI]-V-D-E
FT   ACT_SITE        357
FT                   /note="For ATPase activity"
FT   Condition: E
FT   ACT_SITE        509
FT                   /note="For nuclease activity"
FT   Condition: D
FT   ACT_SITE        581
FT                   /note="For nuclease activity"
FT   Condition: E
FT   ACT_SITE        707
FT                   /note="For nuclease activity"
FT   Condition: D
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Size: 660-747;
Related: None;
Template: P04295;
Scope:
 Viruses; Herpesviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.6 2022/05/03
//