AC   MF_04023;
DC   Protein; auto
TR   HAMAP; MF_04023; -; 1; level=0
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Names: HSV_NEC1
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ID   NEC1
DE   RecName: Full=Nuclear egress protein 1;
GN   Name=NEC1;
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CC   -!- FUNCTION: Plays an essential role in virion nuclear egress, the first
CC       step of virion release from infected cell. Within the host nucleus,
CC       NEC1 interacts with the newly formed capsid through the vertexes and
CC       directs it to the inner nuclear membrane by associating with NEC2.
CC       Induces the budding of the capsid at the inner nuclear membrane as well
CC       as its envelopment into the perinuclear space. There, the NEC1/NEC2
CC       complex promotes the fusion of the enveloped capsid with the outer
CC       nuclear membrane and the subsequent release of the viral capsid into
CC       the cytoplasm where it will reach the secondary budding sites in the
CC       host Golgi or trans-Golgi network.
case <OC:Lymphocryptovirus>
CC   -!- SUBUNIT: Forms a heterodimeric nuclear egress complex (NEC) with NEC2.
CC       4 NEC further associate to form dimers. Interacts with capsid vertex
CC       specific component 2/CVC2; this interaction directs the capsid to the
CC       host inner nuclear membrane to initiate budding.
else
CC   -!- SUBUNIT: Forms a heterohexameric complex with NEC2. Interacts with
CC       capsid vertex specific component 2/CVC2; this interaction directs the
CC       capsid to the host inner nuclear membrane to initiate budding.
end case
CC   -!- SUBCELLULAR LOCATION: Host nucleus inner membrane. Note=Remains
CC       attached to the nucleus inner membrane through interaction with NEC2.
CC   -!- PTM: Phosphorylated at serine residues in the N-terminus. This
CC       phosphorylation regulates the localization within the inner nuclear
CC       membrane.
CC   -!- SIMILARITY: Belongs to the herpesviridae NEC1 protein family.
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DR   Pfam; PF02718; Herpes_UL31; 1; trigger=no
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KW   Host membrane
KW   Host nucleus
KW   Membrane
KW   Metal-binding
KW   Phosphoprotein
KW   Zinc
KW   Zinc-finger
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GO   GO:0044201; C:host cell nuclear inner membrane
GO   GO:0016020; C:membrane
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FT   From: NEC1_HHV11 (P10215)
FT   ZN_FING         106..225
FT                   /note="CCCH-type"
FT   Condition: C-x*-C-x(2)-C-x*-H
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Size: 259-376;
Related: None;
Template: P10215;
Scope:
 Viruses; Herpesviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.4 2022/11/01
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