AC MF_04024; DC Protein; auto TR HAMAP; MF_04024; -; 1; level=0 XX Names: HSV_NEC2 XX ID NEC2 DE RecName: Full=Nuclear egress protein 2; GN Name=NEC2; XX CC -!- FUNCTION: Plays an essential role in virion nuclear egress, the first CC step of virion release from infected cell. Within the host nucleus, CC NEC1 interacts with the newly formed capsid through the vertexes and CC directs it to the inner nuclear membrane by associating with NEC2. CC Induces the budding of the capsid at the inner nuclear membrane as well CC as its envelopment into the perinuclear space. There, the NEC1/NEC2 CC complex promotes the fusion of the enveloped capsid with the outer CC nuclear membrane and the subsequent release of the viral capsid into CC the cytoplasm where it will reach the secondary budding sites in the CC host Golgi or trans-Golgi network. case CC -!- SUBUNIT: Forms a heterodimeric viral nuclear egress complex (NEC) with CC NEC1. else CC -!- SUBUNIT: Forms a heterohexameric complex with NEC1. end case CC -!- SUBCELLULAR LOCATION: Host nucleus inner membrane; Single-pass membrane CC protein. Note=Localizes also at the transient membrane of perinuclear CC virions. CC -!- PTM: Phosphorylated. CC -!- SIMILARITY: Belongs to the herpesviridae NEC2 protein family. XX DR Pfam; PF04541; Herpes_U34; 1; trigger=no DR General; Transmembrane; -; 1; trigger=yes DR ADD_TOPO_DOMAIN; Perinuclear_space; -; 1; trigger=yes DR ADD_TOPO_DOMAIN; Nuclear; -; 1; trigger=yes XX KW Host membrane KW Host nucleus KW Late protein KW Membrane KW Phosphoprotein KW Transmembrane KW Transmembrane helix XX GO GO:0044201; C:host cell nuclear inner membrane GO GO:0016020; C:membrane XX FT None XX Size: 235-398; Related: None; Template: P10218; Scope: Viruses; Herpesviridae Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.4 2022/11/01 //