AC   MF_04029;
DC   Protein; auto
TR   HAMAP; MF_04029; -; 1; level=0
XX
Names: HSV_KITH
XX
ID   KITH
DE   RecName: Full=Thymidine kinase;
DE            EC=2.7.1.21;
GN   Name=TK;
XX
CC   -!- FUNCTION: Catalyzes the transfer of the gamma-phospho group of ATP to
CC       thymidine to generate dTMP in the salvage pathway of pyrimidine
CC       synthesis. The dTMP serves as a substrate for DNA polymerase during
CC       viral DNA replication. Allows the virus to be reactivated and to grow
CC       in non-proliferative cells lacking a high concentration of
CC       phosphorylated nucleic acid precursors.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21;
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the herpesviridae thymidine kinase family.
XX
DR   Pfam; PF00693; Herpes_TK; 1; trigger=no
DR   Pfam; PF08465; Herpes_TK_C; 1; trigger=no
DR   Pfam; PF02489; Herpes_glycop_H; 1; trigger=no
XX
KW   ATP-binding
KW   DNA synthesis
KW   Early protein
KW   Kinase
KW   Nucleotide-binding
KW   Transferase
XX
GO   GO:0005524; F:ATP binding
GO   GO:0004797; F:thymidine kinase activity
GO   GO:0071897; P:DNA biosynthetic process
GO   GO:0006230; P:TMP biosynthetic process
XX
FT   From: KITH_HHV11 (P0DTH5)
FT   BINDING         56..63
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-x-x-x-x-G-K-[TS]
FT   ACT_SITE        83
FT                   /note="Proton acceptor"
FT   Condition: E
FT   BINDING         101
FT                   /ligand="substrate"
FT   Condition: Y
FT   BINDING         125
FT                   /ligand="substrate"
FT   Condition: Q
FT   BINDING         216
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: R
FT   BINDING         222
FT                   /ligand="substrate"
FT   Condition: R
XX
Size: 310-686;
Related: None;
Template: P0DTH5;
Scope:
 Viruses; Herpesviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2022/11/19
//