AC   MF_04030;
DC   Protein; auto
TR   HAMAP; MF_04030; -; 1; level=0
XX
Names: HSV_HELI
XX
ID   HELI
DE   RecName: Full=DNA replication helicase;
DE            EC=3.6.4.-;
GN   Name=HELI;
XX
CC   -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC       the replication forks and generates single-stranded DNA for both
CC       leading and lagging strand synthesis. The primase synthesizes short RNA
CC       primers on the lagging strand that the polymerase elongates using
CC       dNTPs. Possesses helicase-like motifs and therefore may act as the
CC       helicase subunit of the complex.
CC   -!- SUBUNIT: Associates with the primase and the primase-associated factor
CC       to form the helicase-primase complex.
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- SIMILARITY: Belongs to the herpesviridae helicase family.
XX
DR   Pfam; PF02689; Herpes_Helicase; 1; trigger=no
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KW   ATP-binding
KW   DNA replication
KW   Helicase
KW   Host nucleus
KW   Hydrolase
KW   Nucleotide-binding
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GO   GO:0042025; C:host cell nucleus
GO   GO:0005524; F:ATP binding
GO   GO:0004386; F:helicase activity
GO   GO:0039686; P:bidirectional double-stranded viral DNA replication
XX
FT   From: HELI_HHV11 (P10189)
FT   BINDING         97..104
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-x-A-G-x-G-K-[ST]
XX
Size: 781-956;
Related: None;
Template: P10189;
Scope:
 Viruses; Herpesviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.5 2022/11/19
//