AC   MF_04031;
DC   Protein; auto
TR   HAMAP; MF_04031; -; 1; level=0
XX
Names: HSV_DUT
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ID   DUT
DE   RecName: Full=Deoxyuridine 5'-triphosphate nucleotidohydrolase;
DE            Short=dUTPase;
DE            EC=3.6.1.23;
DE   AltName: Full=dUTP pyrophosphatase;
GN   Name=DUT;
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CC   -!- FUNCTION: Involved in nucleotide metabolism: produces dUMP, the
CC       immediate precursor of thymidine nucleotides and decreases the
CC       intracellular concentration of dUTP to avoid uracil incorporation into
CC       viral DNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dUTP + H2O = diphosphate + dUMP + H(+); Xref=Rhea:RHEA:10248,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61555, ChEBI:CHEBI:246422; EC=3.6.1.23;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- SIMILARITY: Belongs to the dUTPase family.
XX
DR   Pfam; PF00692; dUTPase; 1; trigger=no
DR   Pfam; PF04797; Herpes_ORF11; 1; trigger=no
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KW   Hydrolase
KW   Magnesium
KW   Metal-binding
KW   Nucleotide metabolism
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GO   GO:0004170; F:dUTP diphosphatase activity
GO   GO:0046872; F:metal ion binding
GO   GO:0046080; P:dUTP metabolic process
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FT   From: DUT_HHV11 (P10234)
FT   BINDING         260..262
FT                   /ligand="substrate"
FT   Condition: R-S-[SG]
FT   BINDING         366..367
FT                   /ligand="substrate"
FT   Condition: F-G
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Size: 268-436;
Related: None;
Template: P10234;
Scope:
 Viruses; Herpesviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2022/05/14
//