AC   MF_04032;
DC   Protein; auto
TR   HAMAP; MF_04032; -; 1; level=0
XX
Names: HSV_GB
XX
ID   GB
DE   RecName: Full=Envelope glycoprotein B;
DE            Short=gB;
DE   Flags: Precursor;
GN   Name=gB;
XX
CC   -!- FUNCTION: Envelope glycoprotein that forms spikes at the surface of
CC       virion envelope. Essential for the initial attachment to heparan
CC       sulfate moities of the host cell surface proteoglycans. Involved in
CC       fusion of viral and cellular membranes leading to virus entry into the
CC       host cell. Following initial binding to its host receptors, membrane
CC       fusion is mediated by the fusion machinery composed at least of gB and
CC       the heterodimer gH/gL. May be involved in the fusion between the virion
CC       envelope and the outer nuclear membrane during virion egress.
CC   -!- SUBUNIT: Homotrimer; disulfide-linked. Binds to heparan sulfate
CC       proteoglycans. Interacts with gH/gL heterodimer.
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass type I membrane
CC       protein. Host cell membrane; Single-pass type I membrane protein. Host
CC       endosome membrane; Single-pass type I membrane protein. Host Golgi
CC       apparatus membrane; Single-pass type I membrane protein. Note=During
CC       virion morphogenesis, this protein probably accumulates in the
CC       endosomes and trans-Golgi where secondary envelopment occurs. It is
CC       probably transported to the cell surface from where it is endocytosed
CC       and directed to the trans-Golgi network (TGN).
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein B family.
XX
DR   Pfam; PF00606; Glycoprotein_B; 1; trigger=no
DR   Pfam; PF12154; HCMVantigenic_N; 1; trigger=no
DR   General; Signal; -; 1; trigger=yes
DR   General; Transmembrane; -; 1; trigger=no
DR   PROSITE; PS00001; ASN_GLYCOSYLATION; 0-unlimited; trigger=yes
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KW   Disulfide bond
KW   Glycoprotein
KW   Host cell membrane
KW   Host endosome
KW   Host Golgi apparatus
KW   Host membrane
KW   Host-virus interaction
KW   Membrane
KW   Signal
KW   Transmembrane
KW   Transmembrane helix
KW   Viral attachment to host cell
KW   Viral envelope protein
KW   Virion
KW   Virus entry into host cell
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GO   GO:0044175; C:host cell endosome membrane
GO   GO:0044178; C:host cell Golgi membrane
GO   GO:0020002; C:host cell plasma membrane
GO   GO:0016020; C:membrane
GO   GO:0019031; C:viral envelope
GO   GO:0055036; C:virion membrane
GO   GO:0046718; P:viral entry into host cell
GO   GO:0019062; P:virion attachment to host cell
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FT   From: GB_HHV11 (P10211)
FT   TOPO_DOM        Nter..774
FT                   /note="Virion surface"
FT   TRANSMEM        775..795
FT                   /note="Helical"
FT   TOPO_DOM        796..Cter
FT                   /note="Intravirion"
FT   REGION          173..179
FT                   /note="Involved in fusion and/or binding to host membrane"
FT   REGION          258..265
FT                   /note="Involved in fusion and/or binding to host membrane"
FT   REGION          719..772
FT                   /note="Hydrophobic membrane proximal region"
FT   MOTIF           849..852
FT                   /note="Golgi targeting"
FT   Condition: Y-x-x-[LM]
FT   MOTIF           889..892
FT                   /note="Internalization motif"
FT   Condition: Y-x-x-[VL]
FT   DISULFID        116..573
FT   Condition: C-x*-C
FT   DISULFID        133..529
FT   Condition: C-x*-C
FT   DISULFID        207..271
FT   Condition: C-x*-C
FT   DISULFID        364..412
FT   Condition: C-x*-C
FT   DISULFID        596..633
FT   Condition: C-x*-C
XX
Size: 808-980;
Related: None;
Template: P10211;
Scope:
 Viruses; Herpesviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.4 2022/09/29
//