AC   MF_04033;
DC   Protein; auto
TR   HAMAP; MF_04033; -; 1; level=0
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Names: HSV_GH
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ID   GH
DE   RecName: Full=Envelope glycoprotein H;
DE            Short=gH;
DE   Flags: Precursor;
GN   Name=gH;
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CC   -!- FUNCTION: The heterodimer glycoprotein H-glycoprotein L is required for
CC       the fusion of viral and plasma membranes leading to virus entry into
CC       the host cell. Following initial binding to host receptor, membrane
CC       fusion is mediated by the fusion machinery composed of gB and the
CC       heterodimer gH/gL. May also be involved in the fusion between the
CC       virion envelope and the outer nuclear membrane during virion
CC       morphogenesis.
CC   -!- SUBUNIT: Interacts with glycoprotein L (gL); this interaction is
CC       necessary for the correct processing and cell surface expression of gH.
CC       The heterodimer gH/gL seems to interact with gB trimers during fusion.
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Single-pass type I membrane
CC       protein. Host cell membrane; Single-pass type I membrane protein. Host
CC       endosome membrane; Single-pass type I membrane protein. Note=During
CC       virion morphogenesis, this protein probably accumulates in the
CC       endosomes and trans-Golgi where secondary envelopment occurs. It is
CC       probably transported to the cell surface from where it is endocytosed
CC       and directed to the trans-Golgi network (TGN).
CC   -!- PTM: N-glycosylated, O-glycosylated, and sialylated.
CC   -!- SIMILARITY: Belongs to the herpesviridae glycoprotein H family.
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DR   Pfam; PF02489; Herpes_glycop_H; 1; trigger=no
DR   General; Signal; -; 1; trigger=yes
DR   General; Transmembrane; -; 1; trigger=no
DR   PROSITE; PS00001; ASN_GLYCOSYLATION; 0-unlimited; trigger=yes
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KW   Fusion of virus membrane with host cell membrane
KW   Fusion of virus membrane with host membrane
KW   Glycoprotein
KW   Host cell membrane
KW   Host endosome
KW   Host membrane
KW   Membrane
KW   Sialic acid
KW   Signal
KW   Transmembrane
KW   Transmembrane helix
KW   Viral envelope protein
KW   Viral penetration into host cytoplasm
KW   Virion
KW   Virus entry into host cell
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GO   GO:0044175; C:host cell endosome membrane
GO   GO:0020002; C:host cell plasma membrane
GO   GO:0016020; C:membrane
GO   GO:0019031; C:viral envelope
GO   GO:0055036; C:virion membrane
GO   GO:0019064; P:fusion of virus membrane with host plasma membrane
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FT   From: GH_HHV11 (P06477)
FT   TOPO_DOM        Nter..803
FT                   /note="Virion surface"
FT   TRANSMEM        804..824
FT                   /note="Helical"
FT   TOPO_DOM        825..Cter
FT                   /note="Intravirion"
FT   REGION          259..323
FT                   /note="Interaction with gL"
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Size: 686-855;
Related: None;
Template: P06477;
Scope:
 Viruses; Herpesviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.4 2022/09/29
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