AC MF_04034; DC Protein; auto TR HAMAP; MF_04034; -; 1; level=0 XX Names: HSV_GL_alphagamma XX ID GL DE RecName: Full=Envelope glycoprotein L; DE Short=gL; GN Name=gL; XX CC -!- FUNCTION: The heterodimer glycoprotein H-glycoprotein L is required for CC the fusion of viral and plasma membranes leading to virus entry into CC the host cell. Acts as a functional inhibitor of gH and maintains gH in CC an inhibited form. Upon binding to host integrins, gL dissociates from CC gH leading to activation of the viral fusion glycoproteins gB and gH. CC -!- SUBUNIT: Interacts with glycoprotein H (gH); this interaction is CC necessary for the correct processing and cell surface expression of gH. CC The heterodimer gH/gL seems to interact with gB trimers during fusion. CC -!- SUBCELLULAR LOCATION: Virion membrane; Peripheral membrane protein; CC Extracellular side. Host cell membrane; Peripheral membrane protein; CC Extracellular side. Host Golgi apparatus, host trans-Golgi network. CC Note=gL associates with the extravirion surface through its binding to CC gH. During virion morphogenesis, this protein probably accumulates in CC the host trans-Golgi where secondary envelopment occurs. XX DR Pfam; PF12524; GlyL_C; 1; trigger=no DR Pfam; PF05259; Herpes_UL1; 1; trigger=no DR Pfam; PF11108; Phage_glycop_gL; 1; trigger=no DR General; Signal; -; 0-1; trigger=yes DR PROSITE; PS52024; GL_AHV; 0-1; trigger=yes DR PROSITE; PS52026; GL_GHV; 0-1; trigger=yes XX KW Fusion of virus membrane with host cell membrane KW Fusion of virus membrane with host membrane KW Glycoprotein KW Host cell membrane KW Host Golgi apparatus KW Host membrane KW Membrane KW Viral envelope protein KW Viral penetration into host cytoplasm KW Virion KW Virus entry into host cell XX GO GO:0020002; C:host cell plasma membrane GO GO:0019031; C:viral envelope GO GO:0055036; C:virion membrane GO GO:0019064; P:fusion of virus membrane with host plasma membrane XX FT From: GL_HHV11 (P10185) FT REGION 20..161 FT /note="Interaction with gH" XX Size: 137-224; Related: None; Template: P10185; P03212; F5HDB7; Scope: Viruses; Herpesviridae Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.6 2023/07/11 //