AC   MF_04039;
DC   Protein; auto
TR   HAMAP; MF_04039; -; 1; level=0
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Names: HSV_CEP2
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ID   CEP2
DE   RecName: Full=Cytoplasmic envelopment protein 2;
DE   AltName: Full=Tegument protein BGLF2;
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case <OC:Lymphocryptovirus>
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating. Activates the AP-1 pathway and enhances EBV
CC       reactivation and virus release. Inhibits type I IFN-induced TYK2, STAT1
CC       and STAT3 phosphorylation, thereby impairing type I IFN signaling and
CC       counteracting the ability of IFN-alpha to suppress the reactivation of
CC       EBV. Recruits SHP1 phosphatase to dephosphorylate STAT1. Mediates STAT2
CC       ubiquitination and proteasomal degradation. Also suppresses type II and
CC       type III IFN signaling. Contributes to G1/S arrest in the host cell.
CC       Acts as an miRNA regulator that interferes with the function of RISC in
CC       miRNA-mediated mRNA silencing. As a result, SUMOylation is increased.
CC       When encapsulated in the exosomes released by EBV-infected host cells,
CC       may facilitate the infection in recipient cells.
CC   -!- SUBUNIT: Homodimer. Interacts with BBLF1. Interacts with with the
CC       capsid. Interacts with BKRF4 (via C-terminus); this interaction is
CC       important for infectious virion production. Interacts with host TYK2;
CC       this interaction participates to the inhibition of host type I IFN
CC       signaling. Interacts with host STAT1; this interaction leads to STAT1
CC       dephosphorylation and inhibition. Interacts with host STAT2; this
CC       interaction leads to STAT2 degradation. Interacts with host CUL1; this
CC       interaction might facilitate CUL1 recruitment to STAT2, leading to
CC       ubiquitination and degradation of the latter. Interacts with host AGO2;
CC       this interaction participates to the host miRNA regulation leading to
CC       enhanced SUMOylation.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- SUBCELLULAR LOCATION: Virion tegument. Host cytoplasm. Host nucleus.
CC       Host Golgi apparatus, host trans-Golgi network. Note=Localizes in the
CC       host nucleus up to 18 hours postinfection, but at later times localizes
CC       to punctate, cytoplasmic structures. Associates with the capsid before
CC       the final envelopment. Recruited to the TGN via the interaction with
CC       BBLF1. Also found in the exosomes released by the host cell.
else
CC   -!- FUNCTION: Plays a critical role in cytoplasmic virus egress.
CC       Participates in the final step of tegumentation and envelope
CC       acquisition within the host cytoplasm by directly interacting with the
CC       capsid. Upon virion binding to target cell, a signaling cascade is
CC       triggered to disrupt the interaction with the capsid, thereby preparing
CC       capsid uncoating.
CC   -!- SUBUNIT: Interacts with cytoplasmic envelopment protein 3 and with the
CC       capsid.
CC   -!- SUBCELLULAR LOCATION: Virion tegument. Host cytoplasm. Host nucleus.
CC       Note=Localizes in the host nucleus up to 18 hours postinfection, but at
CC       later times localizes to punctate, cytoplasmic structures.
end case
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 2 family.
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DR   Pfam; PF03044; Herpes_UL16; 1; trigger=no
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KW   Host cytoplasm
KW   Host Golgi apparatus
KW   Host nucleus
KW   Late protein
KW   Virion
KW   Virion tegument
case <OC:Lymphocryptovirus>
KW   G1/S host cell cycle checkpoint dysregulation by virus
KW   Inhibition of host STAT1 by virus
KW   Inhibition of host TYK2 by virus
KW   Inhibition of host STAT2 by virus
end case
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GO   GO:0030430; C:host cell cytoplasm
GO   GO:0042025; C:host cell nucleus
GO   GO:0019033; C:viral tegument
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FT   None
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Size: 330-373;
Related: None;
Template: P10200;
Scope:
 Viruses; Herpesviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.4 2022/10/12
//