AC   MF_04042;
DC   Protein; auto
TR   HAMAP; MF_04042; -; 1; level=0
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Names: HSV_CEP3_gammahv
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ID   CEP3
DE   RecName: Full=Cytoplasmic envelopment protein 3;
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CC   -!- FUNCTION: Plays an important role in the cytoplasmic envelopment of
CC       tegument proteins and capsids during the assembly and egress processes.
CC       Participates also in viral entry at the fusion step probably by
CC       regulating the core fusion machinery.
CC   -!- SUBUNIT: Interacts with BGLF2; this interaction is essential for the
CC       proper localization of each protein to the assembly complex and thus
CC       for the production of infectious virus.
CC   -!- SUBCELLULAR LOCATION: Virion tegument. Virion membrane; Lipid-anchor.
CC       Host cell membrane; Lipid-anchor; Cytoplasmic side. Host Golgi
CC       apparatus membrane; Lipid-anchor; Cytoplasmic side. Note=Virion
CC       membrane-associated tegument protein. Associates with host membrane
CC       lipids rafts. During virion morphogenesis, this protein probably
CC       accumulates in the endosomes and trans-Golgi where secondary
CC       envelopment occurs. It is probably transported to the cell surface from
CC       where it is endocytosed and directed to the trans-Golgi network (TGN).
CC   -!- PTM: Myristoylation and palmitoylation (probably on one or more of the
CC       nearby cysteines at the N-terminus) enable membrane-binding and Golgi
CC       apparatus-specific targeting and are essential for efficient packaging.
CC   -!- PTM: Phosphorylated. Phosphorylation does not seem to be required for
CC       recycling to the host Golgi apparatus. Packaging is selective for
CC       underphosphorylated forms.
CC   -!- SIMILARITY: Belongs to the herpesviridae cytoplasmic envelopment
CC       protein 3 family.
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DR   Pfam; PF10813; DUF2733; 1; trigger=no
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KW   Host cell membrane
KW   Host Golgi apparatus
KW   Host membrane
KW   Lipoprotein
KW   Membrane
KW   Myristate
KW   Palmitate
KW   Phosphoprotein
KW   Virion
KW   Virion tegument
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GO   GO:0044178; C:host cell Golgi membrane
GO   GO:0020002; C:host cell plasma membrane
GO   GO:0019033; C:viral tegument
GO   GO:0055036; C:virion membrane
GO   GO:0046760; P:viral budding from Golgi membrane
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FT   From: CEP3_EBVB9 (P0CK51)
FT   INIT_MET        1
FT                   /note="Removed; by host"
FT   Condition: M
FT   LIPID           2
FT                   /note="N-myristoyl glycine; by host"
FT   Condition: G
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Size: 61-91;
Related: None;
Template: P0CK51;
Scope:
 Viruses; Gammaherpesvirinae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.6 2022/10/12
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