AC   MF_04047;
DC   Protein; auto
TR   HAMAP; MF_04047; -; 1; level=0
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Names: ADV_CAP3
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ID   CAP3
DE   RecName: Full=Pre-hexon-linking protein IIIa;
DE   AltName: Full=Capsid vertex-specific component IIIa;
DE            Short=CVSC;
DE   AltName: Full=Protein IIIa;
DE   AltName: Full=pIIIa;
DE   Contains:
DE     RecName: Full=Hexon-linking protein IIIa;
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CC   -!- FUNCTION: [Hexon-linking protein IIIa]: Structural component of the
CC       virion that acts as a cement protein on the capsid interior and which
CC       mediates the interactions between the hexons, including the
CC       peripentonal hexons, and reaches all the way to the penton vertices.
CC       Two hexon linking proteins IIIa, one from each facet, stabilize the
CC       unique edge interface between a pair of facets. As the virus enters the
CC       host cell, hexon linking proteins IIIa are shed concomitant with virion
CC       acidification in the endosome. During virus assembly, seems to play a
CC       role in the serotype specificity of the packaging of viral DNA via its
CC       interaction with packaging protein 3.
CC   -!- SUBUNIT: [Hexon-linking protein IIIa]: Interacts with hexon proteins;
CC       this interaction tethers the peripentonal hexons to hexons situated in
CC       the facet. Interacts with the penton protein (via N-terminus).
CC       Interacts with packaging protein 3; this interaction is required to
CC       promote correct genome packaging. Interacts with hexon-linking protein
CC       VIII.
CC   -!- SUBCELLULAR LOCATION: [Hexon-linking protein IIIa]: Virion. Host
CC       nucleus. Note=Located on the inner side of the capsid shell. 5 copies
CC       cement the gaps between the penton base and peripenton hexons around
CC       each 5-fold axis. Present in 60 copies per virion.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: Cleaved near the C-terminus by the viral protease during virion
CC       maturation to form the mature protein.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell.
CC   -!- SIMILARITY: Belongs to the adenoviridae hexon-linking protein IIIa
CC       family.
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DR   Pfam; PF02455; Hex_IIIa; 1; trigger=no
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KW   Capsid decoration protein
KW   Capsid protein
KW   Host nucleus
KW   Late protein
KW   Phosphoprotein
KW   Viral genome packaging
KW   Virion
KW   Viral release from host cell
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GO   GO:0042025; C:host cell nucleus
GO   GO:0019028; C:viral capsid
GO   GO:0098021; C:viral capsid, decoration
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FT   From: CAP3_ADE05 (P12537)
FT   CHAIN           Nter..Cter
FT                   /note="Pre-hexon-linking protein IIIa"
FT   CHAIN           Nter..570
FT                   /note="Hexon-linking protein IIIa"
FT   PROPEP          571..Cter
FT   REGION          Nter..106
FT                   /note="Peripentonal hexon-tethering domain"
FT   REGION          138..251
FT                   /note="Binding to hexon-linking protein"
FT   SITE            570..571
FT                   /note="Cleavage; by viral protease"
FT   MOD_RES         225
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         274
FT                   /note="Phosphothreonine; by host"
FT   Condition: T
FT   MOD_RES         310
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         444
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         449
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         450
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         452
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         469
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         473
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         490
FT                   /note="Phosphotyrosine; by host"
FT   Condition: Y
FT   MOD_RES         494
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         515
FT                   /note="Phosphoserine; by host"
FT   Condition: S
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Size: 494-615;
Related: None;
Template: P12537;
Scope:
 Viruses; Adenoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Version: 6
# Last updated date: 2025-07-02
# Created date: 2017-02-13
//