AC   MF_04047;
DC   Protein; auto
TR   HAMAP; MF_04047; -; 1; level=0
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Names: ADV_CAP3
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ID   CAP3
DE   RecName: Full=Pre-hexon-linking protein IIIa;
DE   AltName: Full=Capsid vertex-specific component IIIa;
DE            Short=CVSC;
DE   AltName: Full=Protein IIIa;
DE   AltName: Full=pIIIa;
DE   Contains:
DE     RecName: Full=Hexon-linking protein IIIa;
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CC   -!- FUNCTION: Structural component of the virion that acts as a cement
CC       protein on the capsid exterior which mediates the interactions between
CC       the hexons, including the peripentonal hexons, and reaches all the way
CC       to the penton vertices. Two hexon linking proteins IIIa, one from each
CC       facet, stabilize the unique edge interface between a pair of facets. As
CC       the virus enters the host cell, hexon linking proteins IIIa are shed
CC       concomitant with virion acidification in the endosome. During virus
CC       assembly, seems to play a role in the serotype specificity of the
CC       packaging of viral DNA via its interaction with packaging protein 3.
CC   -!- SUBUNIT: Interacts with hexon proteins; this interaction tethers the
CC       peripentonal hexons to hexons situated in the facet. Interacts with the
CC       penton protein (via N-terminus). Interacts with packaging protein 3;
CC       this interaction is required to promote correct genome packaging.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus. Note=Surrounds the border
CC       of each facet on the capsid exterior. Present in around 60 copies per
CC       virion.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: Cleaved near the C-terminus by the viral protease during virion
CC       maturation to form the mature protein.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell.
CC   -!- SIMILARITY: Belongs to the adenoviridae hexon-linking protein IIIa
CC       family.
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DR   Pfam; PF02455; Hex_IIIa; 1; trigger=no
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KW   Capsid decoration protein
KW   Capsid protein
KW   Host nucleus
KW   Late protein
KW   Phosphoprotein
KW   Viral genome packaging
KW   Virion
KW   Viral release from host cell
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GO   GO:0042025; C:host cell nucleus
GO   GO:0019028; C:viral capsid
GO   GO:0098021; C:viral capsid, decoration
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FT   From: CAP3_ADE05 (P12537)
FT   CHAIN           Nter..Cter
FT                   /note="Pre-hexon-linking protein IIIa"
FT   CHAIN           Nter..570
FT                   /note="Hexon-linking protein IIIa"
FT   PROPEP          571..Cter
FT   REGION          Nter..106
FT                   /note="Peripentonal hexon-tethering domain"
FT   REGION          138..251
FT                   /note="Binding to hexon-linking protein"
FT   SITE            570..571
FT                   /note="Cleavage; by viral protease"
FT   MOD_RES         225
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         274
FT                   /note="Phosphothreonine; by host"
FT   Condition: T
FT   MOD_RES         310
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         444
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         449
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         450
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         452
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         469
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         473
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         490
FT                   /note="Phosphotyrosine; by host"
FT   Condition: Y
FT   MOD_RES         494
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         515
FT                   /note="Phosphoserine; by host"
FT   Condition: S
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Size: 494-615;
Related: None;
Template: P12537;
Scope:
 Viruses; Adenoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.4 2019/11/20
//