AC   MF_04049;
DC   Protein; auto
TR   HAMAP; MF_04049; -; 1; level=0
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Names: ADV_CAP8
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ID   CAP8
DE   RecName: Full=Pre-hexon-linking protein VIII;
DE   AltName: Full=Pre-protein VIII;
DE            Short=pVIII;
DE   Contains:
DE     RecName: Full=Hexon-linking protein-N;
DE     AltName: Full=12.1 kDa protein VIII;
DE     AltName: Full=Protein VIII-N;
DE   Contains:
DE     RecName: Full=Hexon-linking protein-C;
DE     AltName: Full=7.6 kDa protein VIII;
DE     AltName: Full=Protein VIII-C;
GN   Name=L4;
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CC   -!- FUNCTION: Hexon-linking protein-N: Structural component of the virion
CC       that acts as a cement protein on the capsid interior and which glue the
CC       peripentonal hexons and group-of-nine hexons together.
CC   -!- FUNCTION: Hexon-linking protein-C: Structural component of the virion
CC       that acts as a cement protein on the capsid interior and which glue the
CC       peripentonal hexons and group-of-nine hexons together.
CC   -!- SUBUNIT: Interacts with the peripentonal hexons as well as the hexons
CC       in the facets. Part of a complex composed of the core-capsid bridging
CC       protein, the endosome lysis protein VI and the hexon-linking protein
CC       VIII; these interactions bridge the virus core to the capsid.
CC   -!- SUBCELLULAR LOCATION: Pre-hexon-linking protein VIII: Host nucleus.
CC   -!- SUBCELLULAR LOCATION: Hexon-linking protein-N: Virion. Note=Located on
CC       the inner side of the capsid shell. Present in 120 copies per virion.
CC   -!- SUBCELLULAR LOCATION: Hexon-linking protein-C: Virion. Note=Located on
CC       the inner side of the capsid shell. Present in 120 copies per virion.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: Cleaved by the viral protease during virion maturation. May cause
CC       the middle segment to be shed from the capsid.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell.
CC   -!- SIMILARITY: Belongs to the adenoviridae hexon-linking protein family.
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DR   Pfam; PF01310; Adeno_PVIII; 1; trigger=no
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KW   Capsid protein
KW   Host nucleus
KW   Late protein
KW   Phosphoprotein
KW   Virion
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GO   GO:0042025; C:host cell nucleus
GO   GO:0019028; C:viral capsid
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FT   From: CAP8_ADE05 (P24936)
FT   CHAIN           Nter..Cter
FT                   /note="Pre-hexon-linking protein VIII"
FT   PEPTIDE         Nter..111
FT                   /note="Hexon-linking protein-N"
FT   PROPEP          112..157
FT   PEPTIDE         158..Cter
FT                   /note="Hexon-linking protein-C"
FT   SITE            111..112
FT                   /note="Cleavage; by viral protease"
FT   SITE            157..158
FT                   /note="Cleavage; by viral protease"
FT   MOD_RES         64
FT                   /note="Phosphothreonine; by host"
FT   Condition: T
FT   MOD_RES         118
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         174
FT                   /note="Phosphoserine; by host"
FT   Condition: S
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Size: 155-278;
Related: None;
Template: P24936;
Scope:
 Viruses; Adenoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.5 2021/10/15
//