AC   MF_04049;
DC   Protein; auto
TR   HAMAP; MF_04049; -; 1; level=0
XX
Names: ADV_CAP8
XX
ID   CAP8
DE   RecName: Full=Pre-hexon-linking protein VIII;
DE   AltName: Full=Pre-protein VIII;
DE            Short=pVIII;
DE   Contains:
DE     RecName: Full=Hexon-linking protein VIII-N;
DE     AltName: Full=12.1 kDa protein VIII;
DE     AltName: Full=Protein VIII-N;
DE   Contains:
DE     RecName: Full=Hexon-linking protein VIII-C;
DE     AltName: Full=7.6 kDa protein VIII;
DE     AltName: Full=Protein VIII-C;
GN   Name=L4;
XX
CC   -!- FUNCTION: [Hexon-linking protein VIII-N]: Structural component of the
CC       virion that acts as a cement protein on the capsid interior and which
CC       glues the peripentonal hexons and group-of-nine hexons together.
CC   -!- FUNCTION: [Hexon-linking protein VIII-C]: Structural component of the
CC       virion that acts as a cement protein on the capsid interior and which
CC       glue the peripentonal hexons and group-of-nine hexons together.
CC   -!- SUBUNIT: Interacts with the peripentonal hexons as well as the hexons
CC       in the facets. Part of a complex composed of the core-capsid bridging
CC       protein, the endosome lysis protein VI and the hexon-linking protein
CC       VIII; these interactions bridge the virus core to the capsid. Interacts
CC       with hexon-linking protein IIIa.
CC   -!- SUBCELLULAR LOCATION: [Pre-hexon-linking protein VIII]: Host nucleus.
CC   -!- SUBCELLULAR LOCATION: [Hexon-linking protein VIII-N]: Virion.
CC       Note=Located on the inner side of the capsid shell. Present in 120
CC       copies per virion.
CC   -!- SUBCELLULAR LOCATION: [Hexon-linking protein VIII-C]: Virion.
CC       Note=Located on the inner side of the capsid shell. Present in 120
CC       copies per virion.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: [Pre-hexon-linking protein VIII]: Cleaved by the viral protease
CC       during virion maturation. May cause the middle segment to be shed from
CC       the capsid.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell.
CC   -!- SIMILARITY: Belongs to the adenoviridae hexon-linking protein family.
XX
DR   Pfam; PF01310; Adeno_PVIII; 1; trigger=no
XX
KW   Capsid protein
KW   Host nucleus
KW   Late protein
KW   Phosphoprotein
KW   Virion
XX
GO   GO:0042025; C:host cell nucleus
GO   GO:0019028; C:viral capsid
XX
FT   From: CAP8_ADE05 (P24936)
FT   CHAIN           Nter..Cter
FT                   /note="Pre-hexon-linking protein VIII"
FT   PEPTIDE         Nter..111
FT                   /note="Hexon-linking protein VIII-N"
FT   PROPEP          112..157
FT   PEPTIDE         158..Cter
FT                   /note="Hexon-linking protein VIII-C"
FT   SITE            111..112
FT                   /note="Cleavage; by viral protease"
FT   SITE            157..158
FT                   /note="Cleavage; by viral protease"
FT   MOD_RES         64
FT                   /note="Phosphothreonine; by host"
FT   Condition: T
FT   MOD_RES         118
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         174
FT                   /note="Phosphoserine; by host"
FT   Condition: S
XX
Size: 155-278;
Related: None;
Template: P24936;
Scope:
 Viruses; Adenoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Version: 8
# Last updated date: 2025-09-18
# Created date: 2017-03-06
//