AC   MF_04052;
DC   Protein; auto
TR   HAMAP; MF_04052; -; 1; level=0
XX
Names: ADV_CAPSP
XX
ID   CAPSP
DE   RecName: Full=Penton protein;
DE            Short=CP-P;
DE   AltName: Full=Penton base protein;
DE   AltName: Full=Protein III;
GN   Name=L2;
XX
case <FTGroup:1>
CC   -!- FUNCTION: Major capsid protein that self-associates to form penton base
CC       pentamers, each in the shape of a pentagon, situated at the 12 vertices
CC       of the pseudo T=25 capsid. Involved in virus secondary attachment to
CC       host cell after initial attachment by the fiber protein. Binds host
CC       integrin heterodimer ITGAV-ITGB5 (alphaV-beta5) thereby triggering
CC       clathrin-mediated endocytosis of virions. Mediates initial virus
CC       attachment to CXADR-negative cells. Binding to integrins ITGAV-ITGB5
CC       also seems to induce macropinocytosis uptake of the virus. As the virus
CC       enters the host cell, penton proteins are shed concomitant with virion
CC       acidification in the endosome.
CC   -!- SUBUNIT: Interacts (via the cell attachment site RGD) with host
CC       heterodimer ITGAV-ITGB5; this interaction promotes virus
CC       internalization. Interacts with host WWP1 and WWP2. Interacts with the
CC       fiber protein (via N-terminal tail region). Interacts with the capsid
CC       vertex protein; this interaction binds the penton base to neighboring
CC       peripentonal hexons.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus. Note=Located at each vertex
CC       of the virion. Present in 60 copies per virion.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- DOMAIN: The cell attachment RGD motif is exposed at the virion surface
CC       and is involved in binding to the integrin heterodimer ITGAV-ITGB5.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell.
CC   -!- SIMILARITY: Belongs to the adenoviridae penton family.
else
CC   -!- FUNCTION: Major capsid protein that self-associates to form penton base
CC       pentamers, each in the shape of a pentagon, situated at the 12 vertices
CC       of the pseudo T=25 capsid. Involved in virus secondary attachment to
CC       host cell after initial attachment by the fiber protein, and in
CC       endocytosis of virions. As the virus enters the host cell, penton
CC       proteins are shed concomitant with virion acidification in the
CC       endosome.
CC   -!- SUBUNIT: Interacts with the fiber protein (via N-terminal tail region).
CC       Interacts with the capsid vertex protein; this interaction binds the
CC       penton base to neighboring peripentonal hexons.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus. Note=Located at each vertex
CC       of the virion.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell.
CC   -!- SIMILARITY: Belongs to the adenoviridae penton family.
end case
XX
DR   Pfam; PF01686; Adeno_Penton_B; 1; trigger=no
XX
case <FTGroup:1>
KW   Clathrin-mediated endocytosis of virus by host
end case
KW   Host-virus interaction
KW   Capsid protein
KW   Host nucleus
KW   Viral penetration into host cytoplasm
KW   Late protein
KW   T=25 icosahedral capsid protein
KW   Viral attachment to host cell
KW   Virion
KW   Virus endocytosis by host
KW   Virus entry into host cell
XX
case <FTGroup:1>
GO   GO:0075512; P:clathrin-dependent endocytosis of virus by host cell
end case
GO   GO:0042025; C:host cell nucleus
GO   GO:0039623; C:T=25 icosahedral viral capsid
GO   GO:0019028; C:viral capsid
GO   GO:0005198; F:structural molecule activity
GO   GO:0019062; P:virion attachment to host cell
XX
FT   From: CAPSP_ADE05 (P12538)
FT   MOTIF           340..342
FT                   /note="Cell attachment site"
FT   Group: 1; Condition: R-G-D
XX
Size: 450-571;
Related: None;
Template: P12538;
Scope:
 Viruses; Adenoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.4 2021/02/25
//