AC   MF_04053;
DC   Protein; auto
TR   HAMAP; MF_04053; -; 1; level=0
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Names: ADV_CORE5
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ID   CORE5
DE   RecName: Full=Core-capsid bridging protein;
DE   AltName: Full=Core protein V;
GN   Name=L2;
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CC   -!- FUNCTION: Associates loosely with the viral DNA to form an outer shell
CC       around the nucleoprotein-DNA complex and links it with the capsid by
CC       binding the endosome lysis protein. Dissociates from the viral genome
CC       during entry. Might be involved in nuclear capsid assembly of the viral
CC       particles through its association with NPM1/nucleophosmin.
CC   -!- SUBUNIT: Monomer. Homodimer. Exists in equilibrium between monomers and
CC       dimers in solution. Interacts with the histone-like nucleoprotein; this
CC       interactions bridge the virus core to the capsid. Interacts with core
CC       protein X; this interactions bridge the virus core to the capsid.
CC       Interacts with the endosome lysis protein VI; this interactions bridge
CC       the virus core to the capsid. Interacts with the peripentonal hexons.
CC       Interacts with host NPM1; this interaction might play a role in virus
CC       assembly.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus, host nucleolus.
CC       Note=Located inside the capsid (core). Present in 157 copies per
CC       virion. Localizes in the nucleoli during infection, then translocates
CC       from the nucleoli to the nucleoplasm as the infection progresses and is
CC       finally incorporated into the viral particles.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- MISCELLANEOUS: This protein is only encoded by mastadenoviruses, and
CC       may therefore play a role in mammals tropism.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell.
CC   -!- SIMILARITY: Belongs to the adenoviridae core-capsid bridging protein
CC       family.
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DR   Pfam; PF03910; Adeno_PV; 1; trigger=no
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KW   DNA-binding
KW   Host nucleus
KW   Late protein
KW   Viral capsid assembly
KW   Virion
KW   Viral release from host cell
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GO   GO:0044196; C:host cell nucleolus
GO   GO:0044423; C:virion component
GO   GO:0003677; F:DNA binding
GO   GO:0019076; P:viral release from host cell
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FT   None
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Size: 228-421;
Related: None;
Template: P36717;
Scope:
 Viruses; Mastadenovirus
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.5 2021/06/04
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