AC   MF_04054;
DC   Protein; auto
TR   HAMAP; MF_04054; -; 1; level=0
XX
Names: ADV_DNB2
XX
ID   DNB2
DE   RecName: Full=DNA-binding protein;
DE            Short=DBP;
DE   AltName: Full=Early 2A protein;
DE   AltName: Full=Early E2A DNA-binding protein;
GN   Name=DBP;
XX
CC   -!- FUNCTION: Plays a role in the elongation phase of viral strand
CC       displacement replication by unwinding the template in an ATP-
CC       independent fashion, employing its capacity to form multimers. Also
CC       enhances the rate of initiation. Released from template upon second
CC       strand synthesis. Assembles in complex with viral pTP, viral pol, host
CC       NFIA and host POU2F1/OCT1 on viral origin of replication. Covers the
CC       whole ssDNA genome during synthesis. The complementary strand synthesis
CC       induces its relese from DNA template. May inhibit cellular
CC       transcription mediated by the interaction between host SRCAP and CBP.
CC   -!- SUBUNIT: Homomultimerizes on viral ssDNA bound to pTP. Forms a
CC       initiation complex with viral polymerase, pTP and hosts NFIA and
CC       POU2F1/OCT1. Interacts with host SRCAP.
CC   -!- SUBCELLULAR LOCATION: Host nucleus. Note=Accumulates in infected cells.
CC   -!- DOMAIN: The C-terminal arm bridges DBP molecules together, thereby
CC       creating a chain.
CC   -!- SIMILARITY: Belongs to the adenoviridae E2A DNA-binding protein family.
XX
DR   Pfam; PF02236; Viral_DNA_bi; 1; trigger=no
DR   Pfam; PF03728; Viral_DNA_Zn_bi; 2; trigger=no
XX
KW   DNA replication
KW   DNA-binding
KW   Early protein
KW   Host nucleus
KW   Host-virus interaction
KW   Metal-binding
KW   Phosphoprotein
KW   Viral DNA replication
KW   Zinc
XX
GO   GO:0042025; C:host cell nucleus
GO   GO:0019028; C:viral capsid
GO   GO:0003677; F:DNA binding
GO   GO:0008270; F:zinc ion binding
GO   GO:0032508; P:DNA duplex unwinding
GO   GO:0045740; P:positive regulation of DNA replication
GO   GO:0006351; P:DNA-templated transcription
GO   GO:0039693; P:viral DNA genome replication
GO   GO:0039687; P:viral DNA strand displacement replication
XX
FT   From: DNB2_ADE05 (P03265)
FT   REGION          297..331
FT                   /note="Flexible loop"
FT   REGION          513..Cter
FT                   /note="C-terminal arm, DBP binding"
FT   BINDING         284
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Condition: C
FT   BINDING         286
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Condition: H
FT   BINDING         339
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Condition: C
FT   BINDING         355
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Condition: C
FT   BINDING         396
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Condition: C
FT   BINDING         398
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Condition: C
FT   BINDING         450
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Condition: C
FT   BINDING         467
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Condition: C
FT   MOD_RES         195
FT                   /note="Phosphotyrosine; by host"
FT   Condition: Y
XX
Size: 397-529;
Related: None;
Template: P03265;
Scope:
 Viruses; Adenoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2022/11/19
//