AC   MF_04055;
DC   Protein; auto
TR   HAMAP; MF_04055; -; 1; level=0
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Names: ADV_DPOL
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ID   DPOL
DE   RecName: Full=DNA polymerase;
DE            EC=2.7.7.7;
GN   Name=POL;
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CC   -!- FUNCTION: Eukaryotic-type DNA polymerase involved in viral genomic
CC       replication. DNA synthesis is protein primed, and acts in a strand
CC       displacement replication. Assembles in complex with viral pTP, DBP,
CC       host NFIA and host POU2F1/OCT1 on viral origin of replication. The
CC       polymerase covalently transfers dCMP onto pTP, thereby initiating
CC       complementary strand synthesis.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- SUBUNIT: Heterodimer with the terminal protein; this heterodimer binds
CC       to bp 9 to 18 of the genome. Forms a complex with viral pTP, DBP and
CC       hosts NFIA and POU2F1/OCT1 for initiation of replication.
CC   -!- SUBCELLULAR LOCATION: Host nucleus.
CC   -!- MISCELLANEOUS: This DNA polymerase requires a protein as a primer.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
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DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1; trigger=no
DR   Pfam; PF03175; DNA_pol_B_2; 1; trigger=no
DR   PRINTS; PR00106; DNAPOLB; 1; trigger=no
DR   PIRSF; PIRSF000788; DPol_ADV; 1; trigger=no
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KW   DNA replication
KW   DNA-binding
KW   DNA-directed DNA polymerase
KW   Host nucleus
KW   Nucleotidyltransferase
KW   Transferase
KW   Viral DNA replication
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GO   GO:0042025; C:host cell nucleus
GO   GO:0008408; F:3'-5' exonuclease activity
GO   GO:0003677; F:DNA binding
GO   GO:0003887; F:DNA-directed DNA polymerase activity
GO   GO:0000166; F:nucleotide binding
GO   GO:0006261; P:DNA-templated DNA replication
GO   GO:0039693; P:viral DNA genome replication
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FT   None
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Size: 1017-1198;
Related: None;
Template: P04495;
Scope:
 Viruses; Adenoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.6 2022/05/03
//