AC   MF_04056;
DC   Protein; auto
TR   HAMAP; MF_04056; -; 1; level=0
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Names: ADV_PVII
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ID   NP
DE   RecName: Full=Pre-histone-like nucleoprotein;
DE   AltName: Full=Pre-core protein VII;
DE            Short=pVII;
DE   Contains:
DE     RecName: Full=Histone-like nucleoprotein;
DE              Short=NP;
DE     AltName: Full=Core protein VII;
GN   Name=L2;
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CC   -!- FUNCTION: Plays a role in the inhibition of host immune response within
CC       the nucleus. Interacts with cellular nucleosomes and immobilizes the
CC       host immune danger signal HMGB1 on chromatin. In turn, prevents HMGB1
CC       release out of the cell and thus decreases inflammation. Plays also a
CC       role in the wrapping and condensation of the viral DNA. May also
CC       promote viral genome import into the nucleus.
CC   -!- SUBUNIT: Interacts with the core-capsid bridging protein; this
CC       interaction bridges the virus core to the capsid. Interacts with host
CC       NPM1; this interaction might play a role in placing the pre-histone-
CC       like nucleoprotein on the viral DNA or regulating viral gene
CC       expression. Interacts with host HMGB1; this interaction inhibits host
CC       immune response.
CC   -!- SUBCELLULAR LOCATION: Pre-histone-like nucleoprotein: Host nucleus,
CC       host nucleolus.
CC   -!- SUBCELLULAR LOCATION: Histone-like nucleoprotein: Virion. Note=Located
CC       inside the capsid in association with the viral DNA (core). Present in
CC       about 1070 copies per virion.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: Cleaved near the N-terminus by the viral protease during virion
CC       maturation to form the mature protein.
CC   -!- MISCELLANEOUS: All late proteins expressed from the major late promoter
CC       are produced by alternative splicing and alternative polyadenylation of
CC       the same gene giving rise to non-overlapping ORFs. A leader sequence is
CC       present in the N-terminus of all these mRNAs and is recognized by the
CC       viral shutoff protein to provide expression although conventional
CC       translation via ribosome scanning from the cap has been shut off in the
CC       host cell.
CC   -!- SIMILARITY: Belongs to the adenoviridae histone-like nucleoprotein
CC       family.
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DR   Pfam; PF03228; Adeno_VII; 1; trigger=no
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case <FTTag:Acet>
KW   Acetylation
end case
KW   DNA-binding
KW   Host nucleus
KW   Host-virus interaction
KW   Late protein
KW   Phosphoprotein
KW   Viral penetration into host nucleus
KW   Virion
KW   Virus entry into host cell
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GO   GO:0044196; C:host cell nucleolus
GO   GO:0003677; F:DNA binding
GO   GO:0046718; P:viral entry into host cell
GO   GO:0075732; P:viral penetration into host nucleus
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FT   From: NP_ADE02 (P68950)
FT   INIT_MET        1
FT                   /note="Removed"
FT   Condition: M
FT   CHAIN           2..Cter
FT                   /note="Pre-histone-like nucleoprotein"
FT   PROPEP          2..24
FT   CHAIN           25..Cter
FT                   /note="Histone-like nucleoprotein"
FT   MOTIF           188..Cter
FT                   /note="Nuclear localization signal"
FT   SITE            24..25
FT                   /note="Cleavage; by viral protease"
FT   Condition: G-A
FT   MOD_RES         2
FT                   /note="N-acetylserine; by host"
FT   Tag: Acet; Condition: S
FT   MOD_RES         27
FT                   /note="N6-acetyllysine; by host"
FT   Tag: Acet; Condition: K
FT   MOD_RES         48
FT                   /note="N6-acetyllysine; by host"
FT   Tag: Acet; Condition: K
FT   MOD_RES         55
FT                   /note="Phosphothreonine; by host"
FT   Condition: T
FT   MOD_RES         74
FT                   /note="Phosphothreonine; by host"
FT   Condition: T
FT   MOD_RES         183
FT                   /note="Phosphoserine; by host"
FT   Condition: S
FT   MOD_RES         185
FT                   /note="Phosphoserine; by host"
FT   Condition: S
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Size: 115-199;
Related: None;
Template: P68950;
Scope:
 Viruses; Adenoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.3 2019/11/20
//