AC   MF_04057;
DC   Protein; auto
TR   HAMAP; MF_04057; -; 1; level=0
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Names: ADV_PKG1
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ID   PKG1
DE   RecName: Full=Packaging protein 1;
DE   AltName: Full=Packaging protein IVa2;
GN   Name=IVa2;
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CC   -!- FUNCTION: Component of the packaging machinery which encapsidates the
CC       viral DNA into preformed capsids and transcriptional activator of the
CC       viral major late promoter (MLP). Binds, along with packaging proteins 2
CC       and 3, to the specific packaging sequence on the left end of viral
CC       genomic DNA and displays ATPase activity thereby providing the power
CC       stroke of the packaging machinery. The activity of packaging protein
CC       IVa2 is stimulated by protein 33K which acts as a terminase. May be the
CC       protein that pumps DNA into the capsid powered by ATP hydrolysis.
CC       Specifically binds to the 5'-CG-3' nucleotides of the repeats making up
CC       the packaging sequence. Component of the DEF-A and DEF-B transcription
CC       factors that bind downstream elements of the major late promoter (MLP),
CC       and stimulate transcription from the MLP after initiation of viral DNA
CC       replication. DEF-A is a heterodimer packaging proteins 1 and 2 and DEF-
CC       B is a homodimer of packaging protein 1.
CC   -!- SUBUNIT: Homodimer. Part of a genome packaging complex composed of
CC       packaging proteins 1, 2 and 3; this complex specifically binds to the
CC       packaging sequence on the left end of viral genomic DNA and performs
CC       packaging of the viral genome. Interacts with protein 33K.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus, host nucleoplasm. Host
CC       nucleus, host nucleolus. Note=Located at a unique vertex of the capsid.
CC       Present in about 6-8 copies per virion.
CC   -!- INDUCTION: Expressed in the intermediate phase of the viral replicative
CC       cycle.
CC   -!- SIMILARITY: Belongs to the adenoviridae packaging protein 1 family.
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DR   Pfam; PF02456; Adeno_IVa2; 1; trigger=no
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KW   Activator
KW   ATP-binding
KW   DNA-binding
KW   Host nucleus
KW   Nucleotide-binding
KW   Phosphoprotein
KW   Transcription
KW   Transcription regulation
KW   Viral genome packaging
KW   Virion
KW   Viral release from host cell
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GO   GO:0044196; C:host cell nucleolus
GO   GO:0044095; C:host cell nucleoplasm
GO   GO:0044423; C:virion component
GO   GO:0005524; F:ATP binding
GO   GO:0003677; F:DNA binding
GO   GO:0039708; P:nuclear capsid assembly
GO   GO:0006355; P:regulation of DNA-templated transcription
GO   GO:0006351; P:DNA-templated transcription
GO   GO:0019073; P:viral DNA genome packaging
GO   GO:0098035; P:viral DNA genome packaging via site-specific sequence recognition
GO   GO:0019076; P:viral release from host cell
GO   GO:0019083; P:viral transcription
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FT   From: PKG1_ADE02 (P03272)
FT   BINDING         171..178
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-P-x-x-x-x-K-S
FT   REGION          440..Cter
FT                   /note="DNA-binding"
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Size: 439-502;
Related: None;
Template: P03272;
Scope:
 Viruses; Adenoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.8 2022/11/19
//