AC MF_04058; DC Protein; auto TR HAMAP; MF_04058; -; 1; level=0 XX Names: ADV_PKG3 XX ID PKG3 DE RecName: Full=Packaging protein 3; DE AltName: Full=L1-52/55 kDa protein; DE AltName: Full=Packaging protein 52K; GN Name=L1; XX CC -!- FUNCTION: Involved in viral genome packaging through its interaction CC with packaging proteins 1 and 2. After proteolyic cleavage by CC adenovirus protease, L1 52/55k protein is removed from the capsid CC during viral maturation. CC -!- SUBUNIT: Part of the genome packaging complex composed of packaging CC proteins 1, 2 and 3; this complex specifically binds to the packaging CC sequence on the left end of viral genomic DNA and performs packaging of CC the viral genome. Interacts with hexon-linking protein IIIa; this CC interaction is required to promote correct genome packaging. CC -!- SUBCELLULAR LOCATION: Host nucleus. Note=Nuclear protein present in CC empty capsids and assembly intermediates. CC -!- INDUCTION: Expressed in the early phase and late phase of the viral CC replicative cycle. CC -!- PTM: Cleaved at different sites by the viral protease during virion CC maturation. CC -!- MISCELLANEOUS: All late proteins expressed from the major late promoter CC are produced by alternative splicing and alternative polyadenylation of CC the same gene giving rise to non-overlapping ORFs. A leader sequence is CC present in the N-terminus of all these mRNAs and is recognized by the CC viral shutoff protein to provide expression although conventional CC translation via ribosome scanning from the cap has been shut off in the CC host cell. CC -!- SIMILARITY: Belongs to the adenoviridae packaging protein 3 family. XX DR Pfam; PF03052; Adeno_52K; 1; trigger=no XX KW Host nucleus KW Late protein KW Phosphoprotein KW Viral genome packaging KW Viral release from host cell XX GO GO:0042025; C:host cell nucleus GO GO:0019073; P:viral DNA genome packaging GO GO:0019076; P:viral release from host cell XX FT From: PKG3_ADE02 (P03262) FT REGION 1..173 FT /note="Interaction with packaging protein 1" FT SITE 351..352 FT /note="Cleavage; by viral protease" FT Condition: T-G FT MOD_RES 75 FT /note="Phosphoserine; by host" FT Condition: S FT MOD_RES 360 FT /note="Phosphoserine; by host" FT Condition: S XX Size: 322-415; Related: None; Template: P03262; Scope: Viruses; Adenoviridae Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.4 2019/11/20 //