AC   MF_04061;
DC   Protein; auto
TR   HAMAP; MF_04061; -; 1; level=0
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Names: ADV_TERM
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ID   TERM
DE   RecName: Full=Preterminal protein;
DE            Short=pTP;
DE   AltName: Full=Bellett protein;
DE   AltName: Full=Precursor terminal protein;
DE   Contains:
DE     RecName: Full=Intermediate terminal protein;
DE              Short=iTP;
DE   Contains:
DE     RecName: Full=Terminal protein;
DE              Short=TP;
GN   Name=PTP;
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CC   -!- FUNCTION: Protein covalently bound to the viral DNA that acts as a
CC       primer for viral genomic replication by DNA strand displacement.
CC       Assembles on the viral origin of replication in an initiation complex
CC       with viral polymerase, DBP, host NFIA and host POU2F1/OCT1. During
CC       initiation, the polymerase covalently couples the first dCTP with Ser-
CC       580 of pTP. The terminal protein stimulates the template activity over
CC       20 fold compared to protein-free templates. Neo-synthesized viral
CC       genomes are linked to two preterminal proteins, one for each 5' end.
CC       These new genomes are encapsidated in the nucleus, and during capsid
CC       maturation by viral protease, preterminal protein is first cleaved into
CC       intermediary (iTP), then into mature TP. May play a role in host
CC       nuclear matrix localization of genomic DNA.
CC   -!- SUBUNIT: Heterodimer with the polymerase; this heterodimer binds to bp
CC       9 to 18 of the genome. Interacts with host POU2F1; POU2F1 binds to the
CC       auxiliary sequences in the inverted terminal repeats and tethers the
CC       pTP-POL heterodimer to the origin DNA thereby participating in the
CC       assembly of the pre-initiation complex (POL-TP-DBP-NFIA-POU2F1).
CC   -!- SUBCELLULAR LOCATION: Host nucleus matrix.
CC   -!- PTM: Preterminal protein is used to replicate viral genome, upon
CC       genomic encapsidation it is processed first into iTP and finally into
CC       TP by adenovirus protease.
CC   -!- SIMILARITY: Belongs to the adenoviridae terminal protein family.
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DR   Pfam; PF02459; Adeno_terminal; 1; trigger=no
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KW   Covalent protein-DNA linkage
KW   DNA replication
KW   DNA-binding
KW   Host nucleus
KW   Phosphoprotein
KW   Viral DNA replication
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GO   GO:0044204; C:host cell nuclear matrix
GO   GO:0042025; C:host cell nucleus
GO   GO:0003677; F:DNA binding
GO   GO:0003690; F:double-stranded DNA binding
GO   GO:0003697; F:single-stranded DNA binding
GO   GO:0039693; P:viral DNA genome replication
GO   GO:0039687; P:viral DNA strand displacement replication
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FT   From: TERM_ADE05 (P04499)
FT   CHAIN           Nter..Cter
FT                   /note="Preterminal protein"
FT   CHAIN           176..Cter
FT                   /note="Intermediate terminal protein"
FT   CHAIN           350..Cter
FT                   /note="Terminal protein"
FT   MOTIF           380..389
FT                   /note="Nuclear localization signal"
FT   SITE            175..176
FT                   /note="Cleavage; by adenovirus protease"
FT   Condition: x-G
FT   SITE            349..350
FT                   /note="Cleavage; by adenovirus protease"
FT   SITE            580
FT                   /note="Priming of strand displacement replication by
FT                   covalently linking the first nucleotide of the new DNA
FT                   chain"
FT   Condition: S
FT   MOD_RES         580
FT                   /note="O-(5'-phospho-DNA)-serine"
FT   Condition: S
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Size: 575-723;
Related: None;
Template: P04499;
Scope:
 Viruses; Adenoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.3 2019/11/20
//