AC MF_04062; DC Protein; auto TR HAMAP; MF_04062; -; 1; level=0 XX Names: INV_PB2 XX ID PB2 DE RecName: Full=Polymerase basic protein 2; DE AltName: Full=RNA-directed RNA polymerase subunit P3; GN Name=PB2; XX case and CC -!- FUNCTION: Plays an essential role in transcription initiation and cap- CC stealing mechanism, in which cellular capped pre-mRNAs are used to CC generate primers for viral transcription. Recognizes and binds the 7- CC methylguanosine-containing cap of the target pre-RNA which is CC subsequently cleaved after 10-13 nucleotides by the viral protein PA. CC Plays a role in the initiation of the viral genome replication and CC modulates the activity of the ribonucleoprotein (RNP) complex. In CC addition, participates in the inhibition of type I interferon induction CC through interaction with and inhibition of the host mitochondrial CC antiviral signaling protein MAVS. CC -!- SUBUNIT: Influenza RNA polymerase is composed of three subunits: PB1, CC PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). CC Interacts with nucleoprotein NP (via N-terminus). Interacts (via N- CC terminus) with host MAVS (via N-terminus); this interaction inhibits CC host innate immune response. CC -!- SUBCELLULAR LOCATION: Virion. Host nucleus. Host mitochondrion. else case and not CC -!- FUNCTION: Plays an essential role in transcription initiation and cap- CC stealing mechanism, in which cellular capped pre-mRNAs are used to CC generate primers for viral transcription. Recognizes and binds the 7- CC methylguanosine-containing cap of the target pre-RNA which is CC subsequently cleaved after 10-13 nucleotides by the viral protein PA. CC Plays a role in the initiation of the viral genome replication and CC modulates the activity of the ribonucleoprotein (RNP) complex. CC -!- SUBUNIT: Influenza RNA polymerase is composed of three subunits: PB1, CC PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). CC Interacts with nucleoprotein NP (via N-terminus). CC -!- SUBCELLULAR LOCATION: Virion. Host nucleus. else CC -!- FUNCTION: Plays an essential role in transcription initiation and cap- CC stealing mechanism, in which cellular capped pre-mRNAs are used to CC generate primers for viral transcription. Recognizes and binds a wide CC range of cap structures of target pre-RNAs which are subsequently CC cleaved after 10-13 nucleotides by the viral protein PA. Plays a role CC in the initiation of the viral genome replication and modulates the CC activity of the ribonucleoprotein (RNP) complex. CC -!- SUBUNIT: Influenza RNA polymerase is composed of three subunits: PB1, CC PB2 and PA. Interacts (via N-terminus) with PB1 (via C-terminus). CC Interacts with nucleoprotein NP (via N-terminus). CC -!- SUBCELLULAR LOCATION: Virion. Host nucleus. end case CC -!- SIMILARITY: Belongs to the influenza viruses PB2 family. XX DR Pfam; PF00604; Flu_PB2; 1; trigger=no XX KW Cap snatching KW Eukaryotic host gene expression shutoff by virus KW Eukaryotic host transcription shutoff by virus KW Host gene expression shutoff by virus KW Host nucleus KW Host-virus interaction case KW Inhibition of host innate immune response by virus KW Inhibition of host MAVS by virus KW Inhibition of host RLR pathway by virus KW Viral immunoevasion KW Host mitochondrion end case KW Inhibition of host RNA polymerase II by virus KW mRNA capping KW mRNA processing KW Viral transcription KW Virion XX case GO GO:0039545; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity GO GO:0033650; C:host cell mitochondrion end case GO GO:0042025; C:host cell nucleus GO GO:0044423; C:virion component GO GO:0003723; F:RNA binding GO GO:0003968; F:RNA-dependent RNA polymerase activity GO GO:0006370; P:7-methylguanosine mRNA capping GO GO:0075526; P:cap snatching GO GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity GO GO:0006351; P:DNA-templated transcription GO GO:0019083; P:viral transcription XX FT From: PB2_I34A1 (P03428) FT MOTIF 736..739 FT /note="Nuclear localization signal" FT Condition: K-R-K-R case FT SITE 627 FT /note="Mammalian adaptation" FT Tag: Hostd; Optional; Condition: K FT SITE 627 FT /note="Avian adaptation" FT Tag: HostA; Optional; Condition: E end case XX Size: 759-774; Related: None; Template: P03428; Scope: Viruses; Orthomyxoviridae Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.9 2022/09/29 //