AC   MF_04063;
DC   Protein; auto
TR   HAMAP; MF_04063; -; 1; level=0
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Names: INFV_PA
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ID   PA
DE   RecName: Full=Polymerase acidic protein;
DE            EC=3.1.-.-;
DE   AltName: Full=RNA-directed RNA polymerase subunit P2;
GN   Name=PA;
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CC   -!- FUNCTION: Plays an essential role in viral RNA transcription and
CC       replication by forming the heterotrimeric polymerase complex together
CC       with PB1 and PB2 subunits. The complex transcribes viral mRNAs by using
CC       a unique mechanism called cap-snatching. It consists in the hijacking
CC       and cleavage of host capped pre-mRNAs. These short capped RNAs are then
CC       used as primers for viral mRNAs. The PB2 subunit is responsible for the
CC       binding of the 5' cap of cellular pre-mRNAs which are subsequently
CC       cleaved after 10-13 nucleotides by the PA subunit that carries the
CC       endonuclease activity.
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC       Note=Binds 2 manganese ions per subunit
CC   -!- SUBUNIT: Influenza RNA polymerase is composed of three subunits: PB1,
CC       PB2 and PA. Interacts (via C-terminus) with PB1 (via N-terminus).
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Host nucleus. Note=PB1 and PA are
CC       transported in the host nucleus as a complex.
CC   -!- PTM: Phosphorylated on serines and threonines by host kinases,
CC       including human casein kinase II.
CC   -!- SIMILARITY: Belongs to the influenza viruses PA family.
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DR   Pfam; PF00603; Flu_PA; 1; trigger=no
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KW   Cap snatching
KW   Endonuclease
KW   Eukaryotic host gene expression shutoff by virus
KW   Eukaryotic host transcription shutoff by virus
KW   Host cytoplasm
KW   Host gene expression shutoff by virus
KW   Host nucleus
KW   Host-virus interaction
KW   Hydrolase
KW   Inhibition of host RNA polymerase II by virus
KW   Manganese
KW   Metal-binding
KW   Nuclease
KW   Phosphoprotein
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GO   GO:0030430; C:host cell cytoplasm
GO   GO:0042025; C:host cell nucleus
GO   GO:0003723; F:RNA binding
GO   GO:0075526; P:cap snatching
GO   GO:0039523; P:suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity
GO   GO:0006351; P:DNA-templated transcription
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FT   From: PA_I34A1 (P03433)
FT   MOTIF           124..139
FT                   /note="Nuclear localization signal 1 (NLS1)"
FT   MOTIF           184..247
FT                   /note="Nuclear localization signal 2 (NLS2)"
FT   BINDING         41
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Condition: H
FT   BINDING         80
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Condition: E
FT   BINDING         108
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Condition: D
FT   BINDING         108
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="2"
FT   Condition: D
FT   BINDING         119
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Condition: E
FT   BINDING         120
FT                   /ligand="Mn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29035"
FT                   /ligand_label="1"
FT   Condition: [IV]
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Size: 709-726;
Related: None;
Template: P03433;
Scope:
 Viruses; Orthomyxoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.8 2022/11/19
//