AC   MF_04064;
DC   Protein; auto
TR   HAMAP; MF_04064; -; 1; level=0
XX
Names: INFV_PB1F2
XX
ID   PB1F2
DE   RecName: Full=Protein PB1-F2;
GN   Name=PB1;
XX
case <FTTag:Signal>
CC   -!- FUNCTION: Plays an important role in promoting lung pathology in both
CC       primary viral infection and secondary bacterial infection. Promotes
CC       alteration of mitochondrial morphology, dissipation of mitochondrial
CC       membrane potential, and cell death. Alternatively, inhibits the
CC       production of interferon in the infected cell at the level of host
CC       mitochondrial antiviral signaling MAVS. Its level of expression differs
CC       greatly depending on which cell type is infected, in a manner that is
CC       independent of the levels of expression of other viral proteins.
CC       Monocytic cells are more affected than epithelial cells. Seems to
CC       disable virus-infected monocytes or other host innate immune cells.
CC       During early stage of infection, predisposes the mitochondria to
CC       permeability transition through interaction with host SLC25A6/ANT3 and
CC       VDAC1. These proteins participate in the formation of the permeability
CC       transition pore complex (PTPC) responsible of the release of
CC       mitochondrial products that triggers apoptosis.
CC   -!- SUBUNIT: Oligomer. Interacts with human SLC25A6/ANT3 and VDAC1.
CC       Interacts with host MAVS.
CC   -!- SUBCELLULAR LOCATION: Host mitochondrion inner membrane. Host nucleus.
CC       Host cytoplasm, host cytosol. Note=Inner mitochondrial membrane in most
CC       cells types. Otherwise is detected in the nucleus and cytosol.
else
CC   -!- FUNCTION: May play an important role in promoting lung pathology in
CC       both primary viral infection and secondary bacterial infection.
CC   -!- SUBCELLULAR LOCATION: Host nucleus. Host cytoplasm, host cytosol.
end case
CC   -!- SIMILARITY: Belongs to the influenza viruses PB1-F2 family.
XX
DR   Pfam; PF11986; PB1-F2; 1; trigger=no
XX
KW   Host cytoplasm
KW   Host nucleus
case <FTTag:Signal>
KW   Apoptosis
KW   Host membrane
KW   Host mitochondrion
KW   Host mitochondrion inner membrane
KW   Host-virus interaction
KW   Inhibition of host innate immune response by virus
KW   Inhibition of host MAVS by virus
KW   Inhibition of host RLR pathway by virus
KW   Membrane
KW   Modulation of host cell apoptosis by virus
KW   Viral immunoevasion
end case
XX
GO   GO:0044164; C:host cell cytosol
GO   GO:0016020; C:membrane
case <FTTag:Signal>
GO   GO:0044192; C:host cell mitochondrial inner membrane
GO   GO:0042025; C:host cell nucleus
GO   GO:0039526; P:perturbation by virus of host apoptosis
GO   GO:0032688; P:negative regulation of interferon-beta production
GO   GO:0039545; P:suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity
end case
XX
FT   From: PB1F2_I34A1 (P0C0U1)
FT   REGION          65..87
FT                   /note="Mitochondrial targeting sequence"
FT   Tag: Signal; Condition: [KR]-x*-[EG]
FT   SITE            66
FT                   /note="High pathogenicity"
FT   Condition: S
FT   SITE            66
FT                   /note="Low pathogenicity"
FT   Condition: N
XX
Size: 11-90;
Related: None;
Template: P0C0U1;
Scope:
 Viruses; Orthomyxoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2023/10/13
//