AC MF_04067; DC Protein; auto TR HAMAP; MF_04067; -; 1; level=0 XX Names: INFV_NEP XX ID NEP DE RecName: Full=Nuclear export protein; DE Short=NEP; DE AltName: Full=Non-structural protein 2; DE Short=NS2; GN Name=NS; XX CC -!- FUNCTION: Mediates the nuclear export of encapsidated genomic RNAs CC (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs CC complexes and the nuclear export machinery of the cell. Possesses no CC intrinsic RNA-binding activity, but includes a C-terminal M1-binding CC domain. This domain is believed to allow recognition of RNPs bound to CC the protein M1. Since protein M1 is not available in large quantities CC before late stages of infection, such an indirect recognition mechanism CC probably ensures that genomic RNPs are not exported from the host CC nucleus until sufficient quantities of viral mRNA and progeny genomic CC RNA have been synthesized. Furthermore, the RNPs enter the host CC cytoplasm only when associated with the M1 protein that is necessary to CC guide them to the plasma membrane. May down-regulate viral RNA CC synthesis when overproduced. CC -!- SUBUNIT: Interacts with protein M1. May interact with host nucleoporin CC RAB/HRB and exportin XPO1/CRM1. CC -!- SUBCELLULAR LOCATION: Virion. Host nucleus. CC -!- SIMILARITY: Belongs to the influenza viruses NEP family. XX DR Pfam; PF00601; Flu_NS2; 1; trigger=no DR Pfam; PF03555; Flu_C_NS2; 1; trigger=no XX KW Host nucleus KW Host-virus interaction KW Transport KW Virion XX GO GO:0042025; C:host cell nucleus GO GO:0044423; C:virion component GO GO:0039675; P:exit of virus from host cell nucleus through nuclear pore GO GO:0006405; P:RNA export from nucleus XX FT From: NEP_I34A1 (P03508) case or FT MOTIF 12..21 FT /note="Nuclear export signal" FT MOTIF 85..94 FT /note="Nuclear export signal" end case FT From: NEP_INCAA (Q01640) case FT MOTIF 96..105 FT /note="Nuclear export signal" FT MOTIF 122..132 FT /note="Nuclear export signal" end case XX Size: 121-182; Related: None; Template: P03508; Q01640; Scope: Viruses; Orthomyxoviridae Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.6 2021/06/04 //