AC   MF_04068;
DC   Protein; auto
TR   HAMAP; MF_04068; -; 1; level=0
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Names: INFV_M1
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ID   M1
DE   RecName: Full=Matrix protein 1;
DE            Short=M1;
GN   Name=M;
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CC   -!- FUNCTION: Plays critical roles in virus replication, from virus entry
CC       and uncoating to assembly and budding of the virus particle. M1 binding
CC       to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral
CC       transcription. Interaction of viral NEP with M1-RNP is thought to
CC       promote nuclear export of the complex, which is targeted to the virion
CC       assembly site at the apical plasma membrane in polarized epithelial
CC       cells. Interactions with NA and HA may bring M1, a non-raft-associated
CC       protein, into lipid rafts. Forms a continuous shell on the inner side
CC       of the lipid bilayer in virion, where it binds the RNP. During virus
CC       entry into cell, the M2 ion channel acidifies the internal virion core,
CC       inducing M1 dissociation from the RNP. M1-free RNPs are transported to
CC       the nucleus, where viral transcription and replication can take place.
CC   -!- FUNCTION: Determines the virion's shape: spherical or filamentous.
CC       Clinical isolates of influenza are characterized by the presence of
CC       significant proportion of filamentous virions, whereas after multiple
CC       passage on eggs or cell culture, virions have only spherical
CC       morphology. Filamentous virions are thought to be important to infect
CC       neighboring cells, and spherical virions more suited to spread through
CC       aerosol between hosts organisms.
CC   -!- SUBUNIT: Homodimer and homomultimer. Interacts with NEP. Binds
CC       ribonucleocapsid by both interacting with genomic RNA and NP protein.
CC       May interact with HA and NA. Cannot bind NP without genomic RNA.
CC   -!- SUBCELLULAR LOCATION: Virion membrane; Peripheral membrane protein;
CC       Cytoplasmic side. Host nucleus.
CC   -!- MISCELLANEOUS: Most abundant protein in virion. When expressed alone
CC       can form virus-like particles in transfected cells.
CC   -!- SIMILARITY: Belongs to the influenza viruses Matrix protein M1 family.
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DR   Pfam; PF00598; Flu_M1; 1; trigger=no
DR   Pfam; PF08289; Flu_M1_C; 1; trigger=no
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KW   Host nucleus
KW   Membrane
KW   RNA-binding
KW   Viral matrix protein
KW   Virion
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GO   GO:0042025; C:host cell nucleus
GO   GO:0055036; C:virion membrane
GO   GO:0003723; F:RNA binding
GO   GO:0039660; F:structural constituent of virion
GO   GO:0046761; P:viral budding from plasma membrane
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FT   From: M1_I34A1 (P03485)
FT   REGION          1..164
FT                   /note="Membrane-binding"
FT   REGION          165..252
FT                   /note="RNP-binding"
FT   MOTIF           101..105
FT                   /note="Nuclear localization signal"
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Size: 248-252;
Related: None;
Template: P03485;
Scope:
 Viruses; Orthomyxoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.3 2019/11/20
//