AC   MF_04070;
DC   Protein; auto
TR   HAMAP; MF_04070; -; 1; level=0
XX
Names: INFV_NCAP
XX
ID   NCAP
DE   RecName: Full=Nucleoprotein;
DE   AltName: Full=Nucleocapsid protein;
DE            Short=Protein N;
GN   Name=NP;
XX
CC   -!- FUNCTION: Encapsidates the negative strand viral RNA, protecting it
CC       from nucleases. The encapsidated genomic RNA is termed the
CC       ribonucleoprotein (RNP) and serves as template for transcription and
CC       replication. The RNP needs to be localized in the host nucleus to start
CC       an infectious cycle, but is too large to diffuse through the nuclear
CC       pore complex. NP comprises at least 2 nuclear localization signals that
CC       are responsible for the active RNP import into the nucleus through
CC       cellular importin alpha/beta pathway. Later in the infection, nclear
CC       export of RNPs are mediated through viral proteins NEP interacting with
CC       M1 which binds nucleoproteins. It is possible that nucleoprotein binds
CC       directly host exportin-1/XPO1 and plays an active role in RNPs nuclear
CC       export. M1 interaction with RNP seems to hide nucleoprotein's nuclear
CC       localization signals. Soon after a virion infects a new cell, M1
CC       dissociates from the RNP under acidification of the virion driven by M2
CC       protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear
CC       localization signals, targeting the RNP to the nucleus.
CC   -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. May bind host
CC       exportin-1/XPO1. Binds to viral genomic RNA. Protein-RNA contacts are
CC       mediated by a combination of electrostatic interactions between
CC       positively charged residues and the phosphate backbone and planar
CC       interactions between aromatic side chains and bases.
CC   -!- SUBCELLULAR LOCATION: Virion. Host nucleus.
CC   -!- PTM: Late in virus-infected cells, may be cleaved from a 56-kDa protein
CC       to a 53-kDa protein by a cellular caspase. This cleavage might be a
CC       marker for the onset of apoptosis in infected cells or have a specific
CC       function in virus host interaction.
CC   -!- SIMILARITY: Belongs to the influenza viruses nucleoprotein family.
XX
DR   Pfam; PF00506; Flu_NP; 1; trigger=no
XX
KW   Capsid protein
KW   Helical capsid protein
KW   Host nucleus
KW   Host-virus interaction
KW   Ribonucleoprotein
KW   RNA-binding
KW   Viral nucleoprotein
KW   Viral penetration into host nucleus
KW   Virion
KW   Virus entry into host cell
XX
GO   GO:0019029; C:helical viral capsid
GO   GO:0042025; C:host cell nucleus
GO   GO:0019013; C:viral nucleocapsid
GO   GO:0003723; F:RNA binding
GO   GO:0005198; F:structural molecule activity
GO   GO:0075732; P:viral penetration into host nucleus
XX
FT   From: NCAP_I34A1 (P03466)
case <OC:Alphainfluenzavirus>
FT   MOTIF           1..18
FT                   /note="Unconventional nuclear localization signal"
FT   MOTIF           198..216
FT                   /note="Bipartite nuclear localization signal"
end case
XX
Size: 498-565;
Related: None;
Template: P03466;
Scope:
 Viruses; Orthomyxoviridae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.4 2019/11/20
//