AC   MF_04094;
DC   Protein; auto
TR   HAMAP; MF_04094; -; 1; level=0
XX
Names: ROTA_A_NSP3
XX
ID   NSP3
DE   RecName: Full=Non-structural protein 3;
DE            Short=NSP3;
DE   AltName: Full=NCVP4;
DE   AltName: Full=Non-structural RNA-binding protein 34;
DE            Short=NS34;
XX
CC   -!- FUNCTION: Plays an important role in stimulating the translation of
CC       viral mRNAs. These mRNAs are capped but not polyadenylated, instead
CC       terminating in a conserved sequence 'GACC' at the 3' that is recognized
CC       by NSP3, which competes with host PABPC1 for EIF4G1 binding. The
CC       interaction between NSP3 and host EIF4G1 stabilizes the EIF4E-EIF4G1
CC       interaction, thereby facilitating the initiation of capped mRNA
CC       translation.
CC   -!- SUBUNIT: Homodimer. Interacts (via the coiled-coil region) with host
CC       ZC3H7B (via LD motif). Interacts with host EIF4G1.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm.
CC   -!- SIMILARITY: Belongs to the rotavirus A NSP3 protein family.
XX
DR   PROSITE; PS50137; DS_RBD; 1; trigger=no
DR   Pfam; PF01665; Rota_NSP3; 1; trigger=no
DR   Pfam; PF00035; dsrm; 1; trigger=no
XX
KW   Coiled coil
KW   Host cytoplasm
KW   Host-virus interaction
KW   RNA-binding
KW   Translation regulation
XX
GO   GO:0003723; F:RNA binding
GO   GO:0006417; P:regulation of translation
XX
FT   From: NSP3_ROTRH (Q8UZL8)
FT   REGION          Nter..149
FT                   /note="RNA-binding"
FT   REGION          150..206
FT                   /note="Dimerization"
FT   REGION          170..234
FT                   /note="Interaction with host ZC3H7B"
FT   REGION          208..Cter
FT                   /note="Interaction with host EIF4G1"
FT   COILED          166..237
XX
Size: 310-315;
Related: MF_04090;
Template: Q8UZL8;
Scope:
 Viruses; Rotavirus
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.3 2019/11/20
//