AC   MF_04101;
DC   Protein; auto
TR   HAMAP; MF_04101; -; 1; level=0
XX
Names: DPOL_T7
XX
ID   DPOL
DE   RecName: Full=DNA-directed DNA polymerase;
DE            EC=2.7.7.7;
DE            EC=3.1.11.-;
XX
CC   -!- FUNCTION: Replicates viral genomic DNA. This polymerase possesses two
CC       enzymatic activities: DNA synthesis (polymerase) and an exonucleolytic
CC       activity that degrades single-stranded DNA in the 3'- to 5'-direction.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
XX
DR   PROSITE; PS00447; DNA_POLYMERASE_A; 1; trigger=no
DR   Pfam; PF00476; DNA_pol_A; 1; trigger=no
DR   Pfam; PF01612; DNA_pol_A_exo1; 1; trigger=no
XX
KW   DNA replication
KW   DNA-binding
KW   DNA-directed DNA polymerase
KW   Exonuclease
KW   Hydrolase
KW   Magnesium
KW   Metal-binding
KW   Multifunctional enzyme
KW   Nuclease
KW   Nucleotidyltransferase
KW   Transferase
KW   Viral DNA replication
XX
GO   GO:0008408; F:3'-5' exonuclease activity
GO   GO:0003677; F:DNA binding
GO   GO:0003887; F:DNA-directed DNA polymerase activity
GO   GO:0000166; F:nucleotide binding
XX
FT   From: DPOL_BPT7 (P00581)
FT   REGION          1..187
FT                   /note="3'-5'exonuclease"
FT   REGION          202..Cter
FT                   /note="Polymerase"
FT   BINDING         5
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /ligand_note="catalytic; for 3'-5' exonuclease
FT                   activity"
FT   Condition: D
FT   BINDING         5
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /ligand_note="catalytic; for 3'-5' exonuclease
FT                   activity"
FT   Condition: D
FT   BINDING         7
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /ligand_note="catalytic; for 3'-5' exonuclease
FT                   activity"
FT   Condition: E
FT   BINDING         174
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /ligand_note="catalytic; for 3'-5' exonuclease
FT                   activity"
FT   Condition: D
FT   BINDING         475
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="3"
FT                   /ligand_note="catalytic; for polymerase activity"
FT   Condition: D
FT   BINDING         475
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="4"
FT                   /ligand_note="catalytic; for polymerase activity"
FT   Condition: D
FT   BINDING         476
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="4"
FT                   /ligand_note="catalytic; for polymerase activity"
FT   Condition: A
FT   BINDING         654
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="3"
FT                   /ligand_note="catalytic; for polymerase activity"
FT   Condition: D
FT   BINDING         654
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="4"
FT                   /ligand_note="catalytic; for polymerase activity"
FT   Condition: D
FT   BINDING         506
FT                   /ligand="substrate"
FT   Condition: H
FT   BINDING         518
FT                   /ligand="substrate"
FT   Condition: R
FT   BINDING         522
FT                   /ligand="substrate"
FT   Condition: K
FT   BINDING         526
FT                   /ligand="substrate"
FT   Condition: Y
XX
Size: 614-904;
Related: None;
Template: P00581;
Scope:
 Viruses; Caudoviricetes
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.8 2022/11/19
//