AC   MF_04105;
DC   Protein; auto
TR   HAMAP; MF_04105; -; 1; level=0
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Names: ANTIH_T4
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ID   ANTIH
DE   RecName: Full=Antiholin;
DE   Flags: Precursor;
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CC   -!- FUNCTION: Involved in lysis inhibition. Senses superinfections and
CC       inhibits the holin, thereby delaying the host cell lysis timing. The
CC       genomic DNA from the superinfecting phage bound to the complex holin-
CC       antiholin probably serves as a signal for the lysis inhibition and
CC       blocks the holin multimerization.
CC   -!- SUBUNIT: Homotetramer; in free-form. Homomultimer. Heterotetramer
CC       composed of 2 holin and 2 antiholin. The holin-antiholin complex binds
CC       dsDNA. Interacts (via C-terminus) with holin (via C-terminus); this
CC       interaction blocks the holin homomultimerization and delays the host
CC       cell lysis.
CC   -!- SUBCELLULAR LOCATION: Host periplasm.
case <FTTag:disulf>
CC   -!- PTM: Disulfide bond is required for functionality.
end case
CC   -!- SIMILARITY: Belongs to the T4likevirus antiholin family.
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DR   General; Signal; -; 1; trigger=yes
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KW   Cytolysis
case <FTTag:disulf>
KW   Disulfide bond
end case
KW   Host cell lysis by virus
KW   Signal
KW   Host periplasm
KW   Viral release from host cell
KW   DNA-binding
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GO   GO:0140678; F:molecular function inhibitor activity
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FT   From: ANTIH_BPT4 (P13304)
FT   DISULFID        69..75
FT   Tag: disulf; Condition: C-x*-C
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Size: 93-100;
Related: None;
Template: P13304;
Scope:
 Viruses; Caudoviricetes
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.9 2022/12/01
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