AC   MF_04108;
DC   Protein; auto
TR   HAMAP; MF_04108; -; 1; level=0
XX
Names: HOLIN_T7
XX
ID   HOLIN
DE   RecName: Full=Holin;
XX
CC   -!- FUNCTION: Accumulates harmlessly in the cytoplasmic membrane until it
CC       reaches a critical concentration that triggers the formation of micron-
CC       scale pores (holes) causing host cell membrane disruption and endolysin
CC       escape into the periplasmic space. Participates in determining the
CC       precise timing of host cell lysis. Participates with the endolysin and
CC       spanin proteins in the sequential events which lead to the programmed
CC       host cell lysis releasing the mature viral particles from the host
CC       cell.
CC   -!- SUBUNIT: Homomultimer.
CC   -!- SUBCELLULAR LOCATION: Host cell inner membrane; Single-pass type II
CC       membrane protein; Periplasmic side. Note=Classified as a class II holin
CC       although it seems to have only one transmembrane domain.
CC   -!- SIMILARITY: Belongs to the T7likevirus holin family.
XX
DR   Pfam; PF10746; Phage_holin_2_2; 1; trigger=no
XX
KW   Cytolysis
KW   Host cell inner membrane
KW   Host cell lysis by virus
KW   Host cell membrane
KW   Host membrane
KW   Membrane
KW   Signal-anchor
KW   Transmembrane
KW   Transmembrane helix
KW   Viral release from host cell
XX
GO   GO:0019835; P:cytolysis
GO   GO:0140911; F:pore-forming activity
GO   GO:0016020; C:membrane
GO   GO:0020002; C:host cell plasma membrane
GO   GO:0019076; P:viral release from host cell
XX
FT   From: HOLIN_BPT7 (P03802)
FT   TOPO_DOM        Nter..36
FT                   /note="Cytoplasmic"
FT   TRANSMEM        37..55
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT   TOPO_DOM        56..Cter
FT                   /note="Periplasmic"
XX
Size: 63-75;
Related: None;
Template: P03802;
Scope:
 Viruses; Caudoviricetes
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2022/12/01
//