AC MF_04109; DC Protein; auto TR HAMAP; MF_04109; -; 1; level=0 XX Names: ENDOLYSIN_LAMBDA XX ID ENLYS DE RecName: Full=Endolysin; DE EC=4.2.2.n2; DE AltName: Full=Transglycosylase; DE AltName: Full=Lysozyme; DE AltName: Full=Lysis protein; XX CC -!- FUNCTION: Endolysin with transglycosylase activity that degrades host CC peptidoglycans and participates with the holin and spanin proteins in CC the sequential events which lead to the programmed host cell lysis CC releasing the mature viral particles. Once the holin has permeabilized CC the host cell membrane, the endolysin can reach the periplasm and break CC down the peptidoglycan layer. CC -!- CATALYTIC ACTIVITY: CC Reaction=Endolytic cleavage of the (1->4)-beta-glycosidic linkage CC between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine CC (GlcNAc) residues in peptidoglycan with concomitant formation of a CC 1,6-anhydrobond in the MurNAc residue.; EC=4.2.2.n2; CC -!- SUBUNIT: Monomer. CC -!- SUBCELLULAR LOCATION: Host cytoplasm. Note=The endolysin is CC cytoplasmic, but can reach the periplasmic space with the help of the CC holins which disrupt the host cell membrane. CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 24 family. XX DR Pfam; PF00959; Phage_lysozyme; 1; trigger=no XX KW Antimicrobial KW Bacteriolytic enzyme KW Cytolysis KW Host cell lysis by virus KW Host cytoplasm KW Lyase KW Viral release from host cell XX GO GO:0003796; F:lysozyme activity GO GO:0016829; F:lyase activity GO GO:0044659; P:viral release from host cell by cytolysis GO GO:0009253; P:peptidoglycan catabolic process XX FT From: ENLYS_LAMBD (P03706) FT ACT_SITE 19 FT Condition: E XX Size: 153-181; Related: None; Template: P03706; Scope: Viruses; Caudoviricetes Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.7 2022/08/23 //