AC   MF_04110;
DC   Protein; auto
TR   HAMAP; MF_04110; -; 1; level=0
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Names: ENDOLYSIN_T4
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ID   ENLYS
DE   RecName: Full=Endolysin;
DE            EC=3.2.1.17;
DE   AltName: Full=Muramidase;
DE   AltName: Full=Lysis protein;
DE   AltName: Full=Lysozyme;
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CC   -!- FUNCTION: Endolysin with lysozyme activity that degrades host
CC       peptidoglycans and participates with the holin and spanin proteins in
CC       the sequential events which lead to the programmed host cell lysis
CC       releasing the mature viral particles. Once the holin has permeabilized
CC       the host cell membrane, the endolysin can reach the periplasm and break
CC       down the peptidoglycan layer.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC         acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC         between N-acetyl-D-glucosamine residues in chitodextrins.;
CC         EC=3.2.1.17;
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Note=The endolysin is
CC       cytoplasmic, but can reach the periplasmic space with the help of the
CC       holins which disrupt the host cell membrane.
case not <FTTag:Act_site>
CC   -!- CAUTION: Lacks the conserved Asp active site.
end case
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 24 family.
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DR   Pfam; PF00959; Phage_lysozyme; 1; trigger=no
DR   PRINTS; PR00684; T4LYSOZYME; 1; trigger=no
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KW   Antimicrobial
KW   Bacteriolytic enzyme
KW   Cytolysis
KW   Glycosidase
KW   Host cell lysis by virus
KW   Host cytoplasm
KW   Hydrolase
KW   Viral release from host cell
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GO   GO:0003796; F:lysozyme activity
GO   GO:0044659; P:viral release from host cell by cytolysis
GO   GO:0009253; P:peptidoglycan catabolic process
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FT   From: ENLYS_BPT4 (P00720)
FT   ACT_SITE        11
FT                   /note="Proton donor/acceptor"
FT   Optional; Condition: E
FT   ACT_SITE        20
FT                   /note="Proton donor/acceptor"
FT   Tag: Act_site; Optional; Condition: [CD]
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Size: 140-380;
Related: MF_04136!;
Template: P00720;
Scope:
 Viruses; Caudoviricetes
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.11 2022/08/23
//