AC   MF_04129;
DC   Protein; auto
TR   HAMAP; MF_04129; -; 1; level=0
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Names: Rota_VP6_A
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ID   VP6
DE   RecName: Full=Intermediate capsid protein VP6;
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CC   -!- FUNCTION: Intermediate capsid protein that self assembles to form an
CC       icosahedral capsid with a T=13 symmetry, which consists of 230 trimers
CC       of VP6, with channels at each of its five-fold vertices. This capsid
CC       constitutes the middle concentric layer of the viral mature particle.
CC       The innermost VP2 capsid and the intermediate VP6 capsid remain intact
CC       following cell entry to protect the dsRNA from degradation and to
CC       prevent unfavorable antiviral responses in the host cell during all the
CC       replication cycle of the virus. Nascent transcripts are transcribed
CC       within the structural confines of this double-layered particle (DLP)
CC       and are extruded through the channels at the five-fold axes. VP6 is
CC       required for the transcription activity of the DLP.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=Component of the intermediate
CC       capsid. Also found in spherical cytoplasmic structures, called virus
CC       factories, that appear early after infection and are the site of viral
CC       replication and packaging.
CC   -!- SUBUNIT: Homotrimer. Interacts with the inner capsid protein VP2.
CC       Interacts with the outer capsid glycoprotein VP7. Interacts with the
CC       outer capsid protein VP5*.
CC   -!- PTM: The N-terminus is blocked.
CC   -!- PTM: Sumoylated with SUMO1 and SUMO2. Sumoylation of viral proteins
CC       seems to have a positive role on viral replication.
CC   -!- MISCELLANEOUS: The VP6 trimer contains a zinc ion located at the center
CC       of the molecule. The zinc ion is not essential for either trimerization
CC       or transcription activity of the DLP. Zinc-depleted VP6 has an
CC       increased sensitivity to proteases.
CC   -!- SIMILARITY: Belongs to the rotavirus VP6 family.
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DR   Pfam; PF00980; Rota_Capsid_VP6; 1; trigger=no
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KW   Calcium
KW   Metal-binding
KW   Zinc
KW   Ubl conjugation
KW   Capsid protein
KW   Intermediate capsid protein
KW   Virion
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GO   GO:0019031; C:viral envelope
GO   GO:0039626; C:viral intermediate capsid
GO   GO:0046789; F:host cell surface receptor binding
GO   GO:0005198; F:structural molecule activity
GO   GO:0019064; P:fusion of virus membrane with host plasma membrane
GO   GO:0046872; F:metal ion binding
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FT   From: VP6_ROTRF (P04509)
FT   BINDING         153
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="ligand shared between all trimeric
FT                   partners"
FT   Condition: H
FT   BINDING         266
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT   Condition: N
FT   BINDING         286
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT   Condition: D
FT   From: VP6_ROTSH (P04509)
FT   REGION          62..73
FT                   /note="Interaction with the inner capsid protein VP2"
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Size: 390-400;
Related: MF_04126;
Template: P04509; A2T3T0; P18610; Q91N61;
Scope:
 Viruses; Rotavirus
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.5 2022/11/19
//