AC   MF_04130;
DC   Protein; auto
TR   HAMAP; MF_04130; -; 1; level=0
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Names: Rota_VP7
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ID   VP7
DE   RecName: Full=Outer capsid glycoprotein VP7;
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CC   -!- FUNCTION: Calcium-binding protein that interacts with rotavirus cell
CC       receptors once the initial attachment by VP4 has been achieved.
CC       Rotavirus attachment and entry into the host cell probably involves
CC       multiple sequential contacts between the outer capsid proteins VP4 and
CC       VP7, and the cell receptors. Following entry into the host cell, low
CC       intracellular or intravesicular Ca(2+) concentration probably causes
CC       the calcium-stabilized VP7 trimers to dissociate from the virion. This
CC       step is probably necessary for the membrane-disrupting entry step and
CC       the release of VP4, which is locked onto the virion by VP7.
CC   -!- SUBUNIT: Homotrimer; disulfide-linked. 2 Ca(2+) ions bound at each
CC       subunit interface in the trimer hold the trimer together. Interacts
CC       with the intermediate capsid protein VP6. Interacts with the outer
CC       capsid protein VP5*.
CC   -!- SUBCELLULAR LOCATION: Virion. Host endoplasmic reticulum lumen.
CC       Note=The outer layer contains 780 copies of VP7, grouped as 260
CC       trimers. Immature double-layered particles assembled in the cytoplasm
CC       bud across the membrane of the endoplasmic reticulum, acquiring during
CC       this process a transient lipid membrane that is modified with the ER
CC       resident viral glycoproteins NSP4 and VP7; these enveloped particles
CC       also contain VP4. As the particles move towards the interior of the ER
CC       cisternae, the transient lipid membrane and the non-structural protein
CC       NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange
CC       to form the outermost virus protein layer, yielding mature infectious
CC       triple-layered particles.
CC   -!- SIMILARITY: Belongs to the rotavirus VP7 family.
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DR   Pfam; PF00434; VP7; 1; trigger=no
DR   General; Signal; -; 1; trigger=yes
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KW   Calcium
KW   Capsid protein
KW   Disulfide bond
KW   Glycoprotein
KW   Host endoplasmic reticulum
KW   Host-virus interaction
KW   Metal-binding
KW   Outer capsid protein
KW   T=13 icosahedral capsid protein
KW   Virion
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GO   GO:0044166; C:host cell endoplasmic reticulum lumen
GO   GO:0039621; C:T=13 icosahedral viral capsid
GO   GO:0039624; C:viral outer capsid
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FT   None
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Size: 240-340;
Related: None;
Template: A2T3P5; P12476; Q86515;
Scope:
 Viruses; Rotavirus
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.3 2019/11/20
//