AC   MF_04137;
DC   Protein; auto
TR   HAMAP; MF_04137; -; 1; level=0
XX
Names: I-SPANIN_LAMBDA
XX
ID   SPAN1
DE   RecName: Full=Spanin, inner membrane subunit;
DE            Short=i-spanin;
DE   AltName: Full=Lysis protein Rz;
XX
CC   -!- FUNCTION: Component of the spanin complex that disrupts the host outer
CC       membrane and participates in cell lysis during virus exit. The spanin
CC       complex conducts the final step in host lysis by disrupting the outer
CC       membrane after holin and endolysin action have permeabilized the inner
CC       membrane and degraded the host peptidoglycans. Host outer membrane
CC       disruption is due to local fusion between the inner and outer membrane
CC       performed by the spanin complex.
case <FTGroup:1>
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Interacts (via C-terminus) with
CC       the spanin outer lipoprotein subunit (via C-terminus). Part of the
CC       spanin complex which spans the entire periplasmic space. The spanin
CC       complex is composed of one homodimer of the i-spanin linked by
CC       intermolecular disulfide bonds involving two Cys residues and one
CC       homodimer of the o-spanin covalently linked by an intermolecular
CC       disulfide bond involving one Cys.
end case
case <AnyFeature:Transmembrane<2>
CC   -!- SUBCELLULAR LOCATION: Host cell inner membrane; Single-pass type II
CC       membrane protein; Periplasmic side.
end case
case <Feature:Coiled_coil>
CC   -!- DOMAIN: The coiled coil region is probably involved in host membrane
CC       fusion leading to lysis.
end case
CC   -!- SIMILARITY: Belongs to the Lambdavirus i-spanin family.
XX
DR   Pfam; PF03245; Phage_lysis; 1; trigger=no
DR   General; Coiled_coil; -; 0-unlimited; trigger=yes
case <Feature:Transmembrane==1>
DR   ADD_TOPO_DOMAIN; Cytoplasmic; -; 1; trigger=yes
DR   ADD_TOPO_DOMAIN; Periplasmic; -; 1; trigger=yes
DR   General; Transmembrane; -; 0-1; trigger=yes
end case
XX
case <Feature:coiled>
KW   Coiled coil
end case
KW   Cytolysis
case <FTGroup:1>
KW   Disulfide bond
end case
case <Feature:Transmembrane>
KW   Signal-anchor
KW   Transmembrane
KW   Transmembrane helix
KW   Host cell inner membrane
KW   Host cell membrane
KW   Host membrane
KW   Membrane
end case
KW   Host cell lysis by virus
KW   Viral release from host cell
XX
GO   GO:0020002; C:host cell plasma membrane
GO   GO:0016020; C:membrane
GO   GO:0044659; P:viral release from host cell by cytolysis
XX
FT   From: SPAN1_LAMBD (P00726)
FT   DISULFID        99
FT                   /note="Interchain"
FT   Group: 1; Condition: C
FT   DISULFID        152
FT                   /note="Interchain"
FT   Group: 1; Condition: C
case not <Feature:Transmembrane==1>
FT   TOPO_DOM        Nter..3
FT                   /note="Cytoplasmic"
FT   TRANSMEM        4..24
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT   TOPO_DOM        25..Cter
FT                   /note="Periplasmic"
end case
XX
Size: 95-195;
Related: None;
Template: P27358;
Scope:
 Viruses
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.9 2022/09/29
//