AC   MF_04139;
DC   Protein; auto
TR   HAMAP; MF_04139; -; 1; level=0
XX
Names: ALT_T4
XX
ID   ALT
case <FTTag:cleavage1> and <FTTag:cleavage2>
DE   RecName: Full=NAD(+)--arginine ADP-ribosyltransferase;
DE            EC=2.4.2.31;
DE   Contains:
DE     RecName: Full=Mature NAD(+)--arginine ADP-ribosyltransferase;
else
DE   RecName: Full=NAD(+)--arginine ADP-ribosyltransferase;
DE            EC=2.4.2.31;
end case
XX
CC   -!- FUNCTION: ADP-ribosyltransferase that efficiently ADP-ribosylates one
CC       of the two alpha subunits of host RNA polymerase RPOA on an arginine
CC       located in the C-terminal region. ADP-ribosylation of RPOA alpha
CC       subunit enhances the transcription of viral early genes. Also
CC       ribosylates RPOA subunits beta, beta' and sigma 70 and performs an
CC       autoribosylation reaction.
CC   -!- SUBCELLULAR LOCATION: Virion. Note=About 25-50 copies per virion. This
CC       protein is injected into the bacterial cell along with the viral DNA.
CC   -!- SIMILARITY: Belongs to the Tevenvirinae NAD(+)--arginine ADP-
CC       ribosyltransferase family.
case <FTTag:Act_site>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-
CC         arginyl-[protein] + nicotinamide + H(+); Xref=Rhea:RHEA:19149,
CC         Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:142554; EC=2.4.2.31;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19150;
end case
case <FTTag:cleavage1> and <FTTag:cleavage2>
CC   -!- PTM: Proteolytic cleavages at the N- and C-termini by the prohead core
CC       protein protease give rise to the mature enzyme.
end case
XX
DR   Pfam; PF03496; ADPrib_exo_Tox; 1; trigger=no
DR   PIRSF; PIRSF000491; Alt_phage; 1; trigger=no
DR   General; Coiled_coil; -; 0-unlimited; trigger=yes
DR   PROSITE; PS51996; TR_MART; 1; trigger=yes
XX
KW   Glycosyltransferase
KW   NAD
KW   Nucleotidyltransferase
KW   Transferase
KW   Virion
XX
GO   GO:0044423; C:virion component
GO   GO:0106274; F:NAD+-protein-arginine ADP-ribosyltransferase activity
GO   GO:0046782; P:regulation of viral transcription
XX
FT   From: ALT_BPT4 (P12726)
FT   CHAIN           Nter..Cter
FT                   /note="NAD(+)--arginine ADP-ribosyltransferase"
FT   SITE            6..7
FT                   /note="Cleavage"
FT   Tag: cleavage1; Optional; Condition: E-[LVS]
FT   SITE            619..620
FT                   /note="Cleavage"
FT   Tag: cleavage2; Optional; Condition: E-S
case <FTTag:cleavage1> and <FTTag:cleavage2>
FT   CHAIN           7..619
FT                   /note="Mature NAD(+)--arginine ADP-ribosyltransferase"
end case
FT   ACT_SITE        576
FT   Tag: Act_site; Condition: E
XX
Size: 600-750;
Related: None;
Template: P12726;
Scope:
 Viruses
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Version: 14
# Last updated date: 2024-09-02
# Created date: 2019-05-21
//