AC   MF_04141;
DC   Protein; auto
TR   HAMAP; MF_04141; -; 1; level=0
XX
Names: MODA_T4
XX
ID   MODA
DE   RecName: Full=NAD--protein ADP-ribosyltransferase modA;
DE            EC=2.4.2.31;
DE   AltName: Full=RNA polymerase ADP-ribosylase modA;
GN   Name=modA;
XX
CC   -!- FUNCTION: ADP-ribosyltransferase that efficiently ADP-ribosylates both
CC       alpha subunits of host RNA polymerase RPOA. The ModA-induced ADP-
CC       ribosylation of RPOA alpha subunits inhibits transcription from viral
CC       early promoters.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-
CC         ribosyl)-L-arginyl-[protein] + nicotinamide; Xref=Rhea:RHEA:19149,
CC         Rhea:RHEA-COMP:10532, Rhea:RHEA-COMP:15087, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:29965, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:142554; EC=2.4.2.31;
CC   -!- SUBCELLULAR LOCATION: Virion. Note=This protein is injected from the
CC       virion into the bacterial cell.
CC   -!- SIMILARITY: Belongs to the Tevenvirinae NAD--protein ADP-
CC       ribosyltransferase modA family.
XX
KW   Glycosyltransferase
KW   Nucleotidyltransferase
KW   Transferase
KW   Virion
XX
GO   GO:0106274; F:NAD+-protein-arginine ADP-ribosyltransferase activity
GO   GO:0044423; C:virion component
XX
FT   From: MODA_BPT4 (P39421)
FT   ACT_SITE        165
FT   Condition: E
FT   BINDING         72
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: R
XX
Size: 190-210;
Related: None;
Template: P39421;
Scope:
 Viruses; Tevenvirinae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.9 2022/11/19
//