AC   MF_04143;
DC   Protein; auto
TR   HAMAP; MF_04143; -; 1; level=0
XX
Names: Poxins
XX
ID   POXIN
case <Feature:PF17057>
DE   RecName: Full=Poxin-Schlafen;
DE            EC=3.1.-.-;
else
DE   RecName: Full=Poxin;
DE            EC=3.1.-.-;
end case
XX
case <OC:Poxviridae>
CC   -!- FUNCTION: Nuclease that is responsible for viral evasion of host cGAS-
CC       STING innate immunity. Cleaves 2',3'-cGAMP which is produced by host
CC       cGAS following recognition of cytosolic DNA and blocks the subsequent
CC       2',3'-cGAMP-mediated activation of TMEM173/STING, which normally
CC       spreads to adjacent cells and activates the interferon and NF-kappa-B
CC       immune responses.
else case <OC:Viruses>
CC   -!- FUNCTION: Nuclease that cleaves host 2',3'-cGAMP.
end case
case <OC:Insecta>
CC   -!- FUNCTION: Nuclease that cleaves 2',3'-cGAMP.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2',3'-cGAMP + H2O = Gp(2'-5')Ap(3') + H(+);
CC         Xref=Rhea:RHEA:59472, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:143093, ChEBI:CHEBI:143098;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:59473;
case <OC:Viruses>
CC   -!- SUBUNIT: Homodimer.
CC   -!- DOMAIN: The substrate binding site is formed by the N-terminus of a
CC       monomer and the C-terminus of the opposite monomer.
end case
case <Feature:PF17057>
CC   -!- SIMILARITY: In the N-terminal section; belongs to the poxin family.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the Schlafen protein
CC       family. Subgroup poxviridae B3 subfamily.
else case <OC:Viruses>
CC   -!- SIMILARITY: Belongs to the poxin family.
else case <OC:Insecta>
CC   -!- SIMILARITY: Belongs to the poxin family. Highly divergent.
CC   -!- CAUTION: The active site cannot be determined by similarity to the
CC       viral poxins.
end case
XX
DR   Pfam; PF04766; Baculo_p26; 1; trigger=no
DR   Pfam; PF04326; AlbA_2; 0-1; trigger=no
DR   Pfam; PF17057; B3R; 0-1; trigger=no
XX
KW   Hydrolase
KW   Nuclease
XX
GO   GO:0061507; F:2',3'-cyclic GMP-AMP binding
GO   GO:0004518; F:nuclease activity
case <OC:Poxviridae>
GO   GO:0052170; P:symbiont-mediated suppression of host innate immune response
end case
XX
FT   From: POXIN_VACCW (Q01225)
case <OC:Viruses>
FT   ACT_SITE        17
FT                   /note="Proton donor"
FT   Condition: H
FT   ACT_SITE        138
FT                   /note="Shared with catalytic histidine of dimeric partner"
FT   Condition: Y
FT   ACT_SITE        142
FT                   /note="Proton acceptor; shared with catalytic histidine of
FT                   dimeric partner"
FT   Condition: K
FT   SITE            60
FT                   /note="Substrate binding"
FT   Condition: R
FT   SITE            105
FT                   /note="Substrate binding"
FT   Condition: I
FT   SITE            149
FT                   /note="Substrate binding"
FT   Condition: N
FT   SITE            169
FT                   /note="Substrate binding"
FT   Condition: Q
FT   SITE            182
FT                   /note="Substrate binding"
FT   Condition: R
FT   SITE            184
FT                   /note="Substrate binding"
FT   Condition: R
FT   SITE            186
FT                   /note="Substrate binding"
FT   Condition: K
end case
FT   From: POXIN_CWPXB (Q8QMP8)
case <Feature:PF17057>
FT   REGION          Nter..238
FT                   /note="Poxin-like"
FT   REGION          239..Cter
FT                   /note="Schlafen-like"
end case
XX
Size: 180-550;
Related: None;
Template: Q01225;
Scope:
 Eukaryota
 Viruses
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2024/03/01
//