AC   MF_04153;
DC   Protein; auto
TR   HAMAP; MF_04153; -; 1; level=0
XX
Names: SSB_T7
XX
ID   SSB
case <OC:Teseptimavirus>
DE   RecName: Full=Single-stranded DNA-binding protein;
DE            Short=SSB protein;
DE   AltName: Full=2.5 protein;
DE   AltName: Full=Gene product 2.5;
DE            Short=gp2.5;
else
DE   RecName: Full=Single-stranded DNA-binding protein;
DE            Short=SSB protein;
DE   AltName: Full=Helix-destabilizing protein;
end case
XX
CC   -!- FUNCTION: Single-stranded DNA-binding protein that participates in
CC       viral DNA replication, formation of concatemers, recombination and
CC       repair of double-stranded breaks. Coats the lagging-strand ssDNA as the
CC       replication fork advances and stimulates the activities of viral DNA
CC       polymerase and primase/helicase. Coordinates simultaneous synthesis of
CC       leading- and lagging-strands. Together with DNA primase/helicase,
CC       promotes pairing of two homologous DNA molecules containing
CC       complementary single-stranded regions and mediates homologous DNA
CC       strand exchange. Promotes also the formation of joint molecules.
CC       Disrupts loops, hairpins and other secondary structures present on
CC       ssDNA to reduce and eliminate pausing of viral DNA polymerase at
CC       specific sites during elongation.
case <OC:Teseptimavirus>
CC   -!- SUBUNIT: Homodimer. Interacts (via C-terminus) with the viral DNA
CC       polymerase. Interacts with the viral helicase/primase. Part of the
CC       replicase complex that includes the DNA polymerase, host thioredoxin,
CC       the primase/helicase and the single-stranded DNA binding protein.
else
CC   -!- SUBUNIT: Homodimer. Interacts (via C-terminus) with the viral DNA
CC       polymerase. Interacts with the viral helicase/primase. Part of the
CC       replicase complex that includes the DNA polymerase, the
CC       primase/helicase and the single-stranded DNA binding protein.
end case
CC   -!- DOMAIN: The acidic C-terminus is involved in modulating the ssDNA
CC       binding properties. It is also required for dimer formation and for
CC       interactions with the viral DNA polymerase and the helicase.
CC   -!- SIMILARITY: Belongs to the Teseptimavirus single-stranded DNA-binding
CC       protein family.
XX
KW   DNA recombination
KW   DNA repair
KW   DNA-binding
KW   Viral DNA replication
XX
GO   GO:0003697; F:single-stranded DNA binding
GO   GO:0006310; P:DNA recombination
GO   GO:0006281; P:DNA repair
GO   GO:0039693; P:viral DNA genome replication
XX
FT   From: SSB_BPT7 (P03696)
FT   REGION          212..232
FT                   /note="Dimerization and interaction with the viral DNA
FT                   polymerase and helicase"
XX
Size: 210-260;
Related: None;
Template: P03696;
Scope:
 Viruses
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.3 2021/02/25
//