AC   MF_04155;
DC   Protein; auto
TR   HAMAP; MF_04155; -; 1; level=0
XX
Names: Helic_T4
XX
ID   HELIC
case <OC:Tequatrovirus>
DE   RecName: Full=DnaB-like replicative helicase;
DE            EC=3.6.4.-;
DE   AltName: Full=Gene product 41;
DE            Short=Gp41;
GN   Name=41;
else
DE   RecName: Full=DnaB-like replicative helicase;
DE            EC=3.6.4.-;
end case
XX
CC   -!- FUNCTION: ATP-dependent DNA helicase essential for viral DNA
CC       replication and recombination. The helicase moves 5' -> 3' on the
CC       lagging strand template, unwinding the DNA duplex ahead of the leading
CC       strand polymerase at the replication fork and generating ssDNA for both
CC       leading and lagging strand synthesis. Interaction with the primase
CC       allows the primase to initiate lagging strand synthesis and fully
CC       activates the helicase. Loaded by the helicase assembly factor on
CC       replication forks that begin at discrete replication origin sequences,
CC       as well as on forks that are created during recombination.
CC   -!- SUBUNIT: Homohexamer. The homohexamer is a trimer of asymmetric dimers.
CC       Interacts with the DNA primase; this interaction forms the active
CC       primosome complex, which is composed of 6 helicase and 1 primase
CC       subunits and expresses full helicase and primase activities. Interacts
CC       (via C-terminus) with the helicase assembly factor; this interaction
CC       brings about the rapid assembly of the helicase onto ssDNA. Part of the
CC       replicase complex that includes the DNA polymerase, the polymerase
CC       clamp, the clamp loader complex, the single-stranded DNA binding
CC       protein, the primase, the DnaB-like replicative helicase and the
CC       helicase assembly factor.
CC   -!- SIMILARITY: Belongs to the helicase family. DnaB subfamily.
XX
DR   PROSITE; PS51199; SF4_HELICASE; 0-1; trigger=yes
DR   Pfam; PF00772; DnaB; 0-1; trigger=no
DR   Pfam; PF03796; DnaB_C; 0-1; trigger=no
DR   Pfam; PF07068; Gp23; 0-1; trigger=no
XX
KW   ATP-binding
KW   DNA replication
KW   DNA-binding
KW   Helicase
KW   Hydrolase
KW   Viral DNA replication
XX
GO   GO:0005524; F:ATP binding
GO   GO:0003678; F:DNA helicase activity
XX
FT   From: HELIC_BPT4 (P04530)
FT   BINDING         197..204
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: [AG]-[AGP]-[IPSTV]-[GHN]-[AFSV]-G-K-[ST]
XX
Size: 380-680;
Related: None;
Template: P04530;
Scope:
 Viruses
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2022/11/19
//