AC MF_04156; DC Protein; auto TR HAMAP; MF_04156; -; 1; level=0 XX Names: HELIC_LOADER_T4 XX ID HLOAD case DE RecName: Full=DNA helicase assembly protein; DE AltName: Full=Gene product 59; DE Short=Gp59; DE AltName: Full=Helicase loader; DE AltName: Full=Helicase loading protein; GN Name=59; else DE RecName: Full=DNA helicase assembly protein; DE AltName: Full=Helicase loader; DE AltName: Full=Helicase loading protein; end case XX CC -!- FUNCTION: DNA helicase loader protein that participates in viral DNA CC replication, recombination, and repair. At the fork, required for CC loading of the replicative helicase onto DNA protected by the ssDNA- CC binding protein. Coordinates simultaneous synthesis of leading- and CC lagging-strands. CC -!- SUBUNIT: Monomer. Homohexamer; when associated with DNA. Interacts (via CC C-terminus) with the DnaB-like replicative helicase (via C-terminus); CC this interaction brings about the rapid assembly of the helicase onto CC ssDNA. Interacts (via C-terminus) with the single-stranded DNA-binding CC protein; a ternary complex between the helicase assembly protein, the CC single-stranded DNA-binding protein and ssDNA is an obligatory CC intermediate in the helicase loading mechanism. Interacts with the CC viral DNA polymerase. Binds to single and double-stranded DNA. Part of the CC replicase complex that includes the DNA polymerase, the polymerase CC clamp, the clamp loader complex, the single-stranded DNA binding CC protein (SSB), the primase, the DnaB-like replicative helicase and the CC helicase assembly factor. CC -!- SIMILARITY: Belongs to the Tequatrovirus DNA helicase assembly protein CC family. XX DR Pfam; PF08993; T4_Gp59_N; 1; trigger=no DR Pfam; PF08994; T4_Gp59_C; 1; trigger=no DR PIRSF; PIRSF004374; Phage-associated_Gp59; 1; trigger=no XX KW Viral DNA replication KW DNA-binding XX GO GO:0003677; F:DNA binding GO GO:0039693; P:viral DNA genome replication XX Size: 150-300; Related: None; Template: P13342; Scope: Viruses; Enterobacteria phage T4 Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.3 2021/03/31 //