AC   MF_04158;
DC   Protein; auto
TR   HAMAP; MF_04158; -; 1; level=0
XX
Names: Antitermination_lambda
XX
ID   REGQ
DE   RecName: Full=Antitermination protein Q;
case <OC:Lambdavirus>
GN   Name=Q;
end case
XX
CC   -!- FUNCTION: Mediates the switch from middle to viral late gene expression
CC       by associating with host RNA polymerase (RNAP) so that the latter can
CC       read without pausing and through transcription terminators preceding
CC       late genes. Competes with host factor sigma 70 for binding to RPOB, the
CC       beta-subunit of host RNAP. To join the elongation complex, binds a
CC       specific DNA Q-binding element (QBE) and interacts with RNAP that is
CC       paused during early elongation. Participates in the lysis-lysogeny
CC       decision by activating the expression of the late lytic genes.
CC   -!- SUBUNIT: Interacts with host RPOB (via flap domain); this interaction
CC       renders host RNAP resistant to transcription pausing and allows it to
CC       read through termination signals. Interacts with host RNA polymerase
CC       sigma factor RPOD (via domain-4). Interacts with host NUSA (via N-
CC       terminus and AR2 domain); this interaction releases the autoinhibition
CC       of NUSA.
CC   -!- SIMILARITY: Belongs to the phage antitermination Q type 2 family.
XX
DR   Pfam; PF03589; Antiterm; 0-2; trigger=no
XX
KW   DNA-binding
KW   Host-virus interaction
KW   Transcription regulation
KW   Transcription termination
case <FTGroup:1>
KW   Zinc
KW   Zinc-finger
KW   Metal-binding
end case
XX
GO   GO:0003677; F:DNA binding
GO   GO:0006353; P:DNA-templated transcription termination
GO   GO:0006355; P:regulation of DNA-templated transcription
GO   GO:0031564; P:transcription antitermination
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: REGQ_LAMBD (P03047)
case <FTGroup:1>
FT   ZN_FING         118..147
end case
FT   DNA_BIND        171..192
FT   BINDING         118
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         121
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         144
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   BINDING         147
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT   Group: 1; Condition: C
FT   SITE            101
FT                   /note="Interaction with host rpoB"
FT   Optional; Condition: T
FT   SITE            134
FT                   /note="Interaction with host RNA polymerase sigma factor
FT                   RPOD"
FT   Optional; Condition: E
FT   SITE            160
FT                   /note="Interaction with host rpoB"
FT   Optional; Condition: A
FT   SITE            165
FT                   /note="Interaction with host rpoB"
FT   Optional; Condition: T
XX
Size: 190-280;
Related: None;
Template: P03047;
Scope:
 Viruses
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2022/11/19
//