AC   MF_04161;
DC   Protein; auto
TR   HAMAP; MF_04161; -; 1; level=0
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Names: Sliding_clamp_T4
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ID   CLAMP
DE   RecName: Full=Sliding clamp;
DE   AltName: Full=DNA polymerase accessory protein Gp45;
DE   AltName: Full=DNA polymerase clamp;
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CC   -!- FUNCTION: Sliding clamp that encircles the genomic DNA and links the
CC       DNA polymerase to the template to control the processivity of DNA
CC       synthesis. Responsible for tethering the catalytic subunit of DNA
CC       polymerase to DNA during high-speed replication. Interaction with the
CC       sliding-clamp-loader opens the sliding clamp so that it can be loaded
CC       around the DNA template. During transcription, encircles the DNA and
CC       tethers host RNA polymerase (RNAP) to it.
CC   -!- SUBUNIT: Homotrimer. Interacts with the viral DNA polymerase; this
CC       interaction constitutes the polymerase holoenzyme. Interacts with the
CC       sliding-clamp-loader; this interaction allows the sliding-clamp-loader
CC       to open the sliding clamp. Interacts with the viral DNA ligase. Part of
CC       the replicase complex that includes the DNA polymerase, the polymerase
CC       clamp, the clamp loader complex, the single-stranded DNA binding
CC       protein, the primase, the helicase and the helicase assembly factor.
CC       Interacts with the viral RNA polymerase (RNAP). Part of the
CC       transcription activation complex containing host RNAP, the viral RNA
CC       polymerase sigma-like factor, the late transcription coactivator, and
CC       the sliding clamp.
CC   -!- SIMILARITY: Belongs to the Tevenvirinae sliding clamp family.
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DR   Pfam; PF02916; DNA_PPF; 0-1; trigger=no
DR   Pfam; PF09116; gp45-slide_C; 0-1; trigger=no
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KW   DNA replication
KW   Viral DNA replication
KW   Viral transcription
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GO   GO:0030337; F:DNA polymerase processivity factor activity
GO   GO:0039693; P:viral DNA genome replication
GO   GO:0019083; P:viral transcription
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FT   None
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Size: 190-250;
Related: None;
Template: P04525;
Scope:
 Viruses
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.2 2021/04/20
//