AC   MF_04162;
DC   Protein; auto
TR   HAMAP; MF_04162; -; 1; level=0
XX
Names: T4_Clamp_Loader_L
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ID   LOADL
DE   RecName: Full=Sliding-clamp-loader large subunit;
DE            EC=3.6.4.-;
DE   AltName: Full=Clamp loader gp44 subunit;
XX
CC   -!- FUNCTION: Forms the sliding-clamp-loader together with the small
CC       subunit. Functions as an ATPase enzyme. The clamp loader holds the
CC       clamp in an open conformation and places it onto the DNA. 4 ATP
CC       molecules must bind to the sliding-clamp-loader before the latter can
CC       open the sliding clamp. ATP hydrolysis triggers the detachment of the
CC       sliding clamp from the sliding-clamp-loader, freeing the sliding clamp
CC       to track along DNA.
CC   -!- SUBUNIT: The sliding-clamp-loader consists of 4 large subunits and 1
CC       small subunit. Interacts with the sliding clamp; this interaction
CC       allows the sliding-clamp-loader to open the sliding clamp. Part of the
CC       replicase complex that includes the DNA polymerase, the polymerase
CC       clamp, the clamp loader complex, the single-stranded DNA binding
CC       protein, the primase, the helicase and the helicase assembly factor.
CC   -!- SIMILARITY: Belongs to the Tevenvirinae sliding-clamp-loader large
CC       subunit family.
XX
DR   Pfam; PF00004; AAA; 0-1; trigger=no
DR   Pfam; PF06144; DNA_pol3_delta; 0-1; trigger=no
DR   Pfam; PF08542; Rep_fac_C; 0-1; trigger=no
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KW   ATP-binding
KW   Viral DNA replication
KW   DNA-binding
KW   Hydrolase
KW   Nucleotide-binding
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GO   GO:0005524; F:ATP binding
GO   GO:0003677; F:DNA binding
GO   GO:0039693; P:viral DNA genome replication
GO   GO:0003689; F:DNA clamp loader activity
GO   GO:0016887; F:ATP hydrolysis activity
XX
FT   From: LOADL_BPT4 (P04526)
FT   BINDING         12..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: [DEILSTV]-[EILMNQ]-[KR]-Y
FT   BINDING         53..58
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: G-x-G-K-[ST]-[ST]
FT   BINDING         24
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: [ILV]
FT   BINDING         205
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: R
XX
Size: 260-490;
Related: None;
Template: P04526;
Scope:
 Viruses
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2022/11/19
//